胃癌组织中明胶酶A的表达

Expression of gelatinase A in human gastric carcinoma

目的 探讨明胶酶A在胃癌组织中的表达及其意义。方法 采用免疫组化方法检测 3 6例胃癌组织明胶酶A的表达。结果 明胶酶A在正常胃组织中表达极低 (2 /14 ) ,癌旁组织低表达 (7/18) ,胃癌组织高表达 (3 1/3 6)。明胶酶A表达与胃癌大小、Lauren分型无关。早期胃癌不表达 ,进展期胃癌特别是有浆膜侵袭和转移者 ,其明胶酶A呈显著高表达。明胶酶A表达定位于胃癌基质 ,以巨噬细胞为主。结论 明胶酶A表达可作为判断胃癌侵袭与转移的标志 ;

Objective To study the significance and expression of gelatinase A in human gastric cancers (GC). Method Gelatinase A expression in 36 cases of GC was examined by immunohistochemistry method. Results Expression of gelatinase A in GC (31/36) was much higher than that in paratumor tissues (7/18) or normal gastric tissues (2/14). There was no obvious correlation between the total gelatinase A staining and tumor size, Lauren typing . Intense expression of gelatinase A was freguently found in the advanced cancer, especially in GC with serosal invasion and lymph node metastasis, while expression of gelatinase A was not found in the early stage GC. Gelatinase A was shown to be expressed in the extracellur matrix of tumor tissues. The staining positive cells were mainly macrophages. Conclusions Gelatinase A expression could be used as a marker for evaluating the invasion and metastasis of GC. Macrophages may play an important role in this process.