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缺氧诱导因子-1与肿瘤 被引量:1

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摘要 缺氧诱导因子 1(hypoxiainduciblefactor 1,HIF 1)是调控细胞氧平衡和诱导缺氧反应基因表达的重要的DNA结合蛋白 ,与肿瘤的发生、发展密切相关。HIF 1受多种抑癌基因、癌基因、生长因子的调节 ,参与对肿瘤生理过程的调控。了解HIF 1的作用机制 ,人工调控肿瘤组织内的HIF 1水平有助于对肿瘤的治疗。
作者 喻晓蔚
出处 《中国肿瘤》 CAS 2002年第5期286-288,共3页 China Cancer
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  • 1Chi V. Dang,Brian C. Lewis,Christine Dolde,Gerard Dang,Hyunsuk Shim. Oncogenes in Tumor Metabolism, Tumorigenesis, and Apoptosis[J] 1997,Journal of Bioenergetics and Biomembranes(4):345~354

同被引文献22

  • 1Semenza GL, AgaNi F, Booth G, et al. Structural and functional analysis of hypoxia- inducible factor 1[J]. Kidney Int, 1997;51:553-555.
  • 2Minet E, Michel G, Remacle P, et al. Role of HIF - 1 as a transciption factor involved in embryonic development, cealcer progression and apoptosis [J]. Int J Mol Meal, 2000;5:253- 259.
  • 3Maxwell PH, Dachs GU, Gleadle JM, et al. Hypoxia - inducible factor 1 modulates gene exwession in solid tumors and influences both anglogenesis mad tumor growth [J]. Pro Natl Acad Sci USA, 1997;94:8104- 8109.
  • 4Maxwell PH, Dachs GU, Gleadie JM, et al. Hypoxia - inducible factor 1 modulalates gene expression in solid tumors and influences both angiogenesis and tumor growth [J]. Pro Nail Acad Sci USA, 1997;94:8104- 8109.
  • 5Ivan M, Kaelin WG.The von Hippel - Idndau tumor suppressor protein[J]. Curt Opin Genet Dev, 2001 ; 11:27 - 34.
  • 6Boast K, Binley K, Iqbau S, et al. Characterization of physiologically regulated vectors for the treatment of ischemic disease [ J ]. Human Gene Therapy, 1999; 10:2197 -2208.
  • 7Zhong H, Agani F Baccala .AA, et al. Increased expression of hypoxia inducible factor- lalpha in rat and human prostate cancer [J]. Cancer Res 1998 ; 58 : 5280 - 5284.
  • 8Martin C, Yu AY, Jiang BH, et al. Cardiac hypertrophy in chronically anemic fetal sheep: increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia- inducible factor 1 [J]. Am J Obstet Gynecol, 1998; 178:527 - 534.
  • 9Lee SH, Wolf PL, Escudem R, et al. Early expression of angiogenesis factors in acute myocardial ischemia mid infarction [J]. N Engl J Med, 20(10;342:626 - 633.
  • 10Semenza GL, Regulation of mammalian O2 homeostasis by hypoxia -inducible factor 1 [J]. Annu Rev Cell Dev Biol, 1999; 15:551 - 578.

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