高血压病球结膜微循环定量指标研究

A Quantitative Study on Microcirculation of Conjunctivae Bulbar in Hypertension

利用微循环图像计算机处理系统,对高血症病人及正常人各30例作了球结膜微循环检查。指标:管径(A_1～A_4,V_1～V_4——田氏生血管分级法)、单根血管流速、流量、微血管灌流百分比。治疗前,病人组所有指标均低于正常(P<0.05),且A_1、A_2管径与肱动脉舒张压(DP)呈负相关(r分别为-0.62、-0.86,n=30,P<0.05);回归方程:A_1=18.30、A_2=29.87-0.10DP。治疗后,尽管流速减慢,但流量无变化;而其余指标则均明显增加(P=<0.05)。由此可以得出如下结论:高血压微循环障碍的重要特征为微血管痉挛、狭窄、微血管网开放度减少和血流状态恶化;而降压治疗则可降低外周阻力,改善微循环。

Thirty cases of both patients with hypertension and normal peoples were respectively studied with a system of video-microscope and computer. Observed items: diameter of microvessels(Al ~ A4,V1 ~ V4——Tianniu's Methods), blood flow velocity and quantity of single vessel, percentage of perfused vessels. Before treatment, all parameters in patients were lower than that in normal peoples; and the diameters of Al, A2 were significantly negatively correlated with the diastolic pressure (DP) of brachial artery(r = -0.62 vs = - 0.86, n = 30, P < 0.05);regression equation: Al = 18.30 - 0.02DP.A2 = 29.87 - 0.10DP) .After treatment,although blood flow velocity reduced,but quantity of blood flow did not change;and other parameters apparently increased.So a conclusion can be the drawn that most important characteristics of microcirculation disturbance in hypertension are spasm and narrow of mi-crovessels, decrease in the opening degree of microvessel network, and a deterioration of blood flow state. Antihypertension treatment is able to reduce the peripheral resistance and improve the microcirculation circumstance.