急性心肌梗死患者溶栓前后患者血浆中NO、vWF的动态观察

The dynamic changes of plasma nitric oxide and von Willebrand Factor levels in patients with acute myocardial infarction freated by intravenous thrombolytic therapy

目的 探讨急性心肌梗死 (AMI)溶栓前后患者血浆中NO、vWF的动态变化及其临床意义。方法 对 4 1例AMI溶栓前及溶栓后 2h、2 4h分别采血 ,测取血浆中NO及vWF的含量 ,并进行统计学处理比较。结果 2 4例溶栓再通后2h ,患者血浆中NO显著降低 ,P <0 0 1,vWF无明显变化 >0 0 5 ;2 4h ,患者血浆中NO显著增高 ,P >0 0 1,vWF显著降低 ,P <0 0 1;而未再通组溶栓后 2h、2 4hNO及vWF的含量均无显著差异P >0 0 5。结论 AMI溶栓再通患者血浆中NO明显增高 ,vWF明显下降 ;

Objectives To investigate the changes and clinical meaning of NO. vWF in the plasma of patients which happens before and after thrombolytic therapy of acute myocardial infarction. Methods Plasma NO and vWF were measured in 41 patients with AMI before and after thrombolytic therapy at 2 h, 24 h respectively. Results 2 hours after thrombolytic repass in 24 examples, the content of NO in the patients plasma decreases obviously, P <0 01, no obvious change in vWF, P >0 05. 24 hours after thrombolytic therapy, the content of NO increases obviously, P <0 01. But non patent group, it is no obvious change that the content of NO and vWF in patients plasma after two and 24 hours thrombolytic therapy. Conclusions The thrombolytic repass of AMI, it is quite obvious that NO in patient plasma has become higher and vWF lower, But in nonpatent group, the content of NO and vWF is no obrious change.