妊娠期糖尿病的筛检及相关危险因素的研究

Screening and Risk Factors of Gestational Diabetes Mellitus in Tianjin City

目的 探讨妊娠期糖尿病(GDM)相关危险因素,为预防GDM的发生提供科学依据。方法 共501位孕妇接受筛检,其中16例诊断为GDM。研究数据通过问卷调查和测量得到。用非条件Logistic回归分析来探讨GDM发生的危险因素。结果 单因素回归分析显示:年龄、糖尿病家族史、经产史、既往多囊卵巢综合症、初孕年龄、孕前体重、孕前体重指数和孕前腰围与孕妇GDM发生有关联。多因素分析表明:初孕年龄(OR＝4.1102,95%CI:1.2610-13.3965)、糖尿病家族史(OR＝6.6138,95%CI:1.3334-32.8063)、孕前 BMI(OR＝16.8227,95%CI:5.5441-51.0457)增加孕妇发生GDM的危险。结论 加强对初孕年龄大、有糖尿病家族史、孕前BMI值大的孕妇的检查,以预防GDM的发生。

Objective To determine the risk factors related to Gestational diabetes mellitus (GDM) and to provide scientific basis for GDM prevention.Methods A total of 501 pregnant women were screened and 16 cases were found with GDM. Data were obtained using questionnaires and measurement respectively. Non-con ditional logistic regressions were used to identify the risk factors of GDM. Results Single-factor logistic regres sion showed that age,family history of DM, past parity, polycystic ovary syndrome(PCOS) , first gestational age, pre-pregnancy weight, pre-pregnancy BMI, pre-pregnancy waist circumference were associated with GDM. Multi-factors non-conditional logistic regression showed that first gestational age( OR=4.1102, 95% CI:1. 2610-13.3965), family history of DM( OR = 6.6138, 95%CI: 1.3334-32.8063) and pre - pregnancy BMI (OR=16.8227, 95% CI:5.5441-51.0457) were the risk factors of GDM. Conclusion It is necessary to strengthen examination in pregnant women with advanced first gestational age, family history of DM or big pre-pregnancy BMI in GDM prevention.