基质金属蛋白酶-2和基质金属蛋白酶-9在前列腺癌组织中表达的免疫组织化学研究

Immunohistochemical studies of the expression of matrix metall oproteinase-2 and metalloproteinase-9 in human prostate cancer

目的 :探讨基质金属蛋白酶 2 (MMP 2 )和基质金属蛋白酶 9(MMP 9)在前列腺癌组织中的表达及其与前列腺癌侵袭的关系。方法 :采用免疫组织化学方法检测前列腺癌组织及良性前列腺增生组织中MMP 2和MMP 9的表达。结果 :前列腺癌组织中MMP 2和MMP 9的表达显著高于良性前列腺增生组织 (P <0 .0 1)。前列腺癌组织中MMP 2、MMP 9的表达与侵袭程度呈正相关。结论 :MMP 2和MMP 9是检测前列腺癌较好的分子标志 ,可用于前列腺癌的辅助诊断和预后判断。

Purpose:To study the express of matrix metalloproteinase-2 and -9 in human prostate cancer.Methods:Matrix metalloproteinase-2 and -9 were detected by immunohistochemistry method in tissues of prostate cancer and BPH. Results:The matrix metalloproteinase-2 and -9 levels in prostate cancer were much higer than those in BPH, and the degree of cancer invasion positively correlated with the expression of the metalloproteinases. Conclusions:Matrix metalloproteinase-2 and -9 are pretty good molecular markers of prostate cancer which can be used to assist diagnosis and predict prognosis.