血管内皮生长因子及微血管密度与胃癌进展的关系

The Correlation Between Vascular Endothelial Growth Factor, Microvessel Density and the Progression of Gastric Carcinoma

目的 探讨血管内皮生长因子 (VEGF)及微血管密度 (MVD)与胃癌临床病理因素的关系。方法 应用免疫组织化学 (SP)方法测定胃癌及胃良性病变中VEGF表达及MVD。结果 胃癌组VEGF表达阳性率为 75 .0 % ,胃良性病变组为 5 .0 % (P<0 .0 5 ) ;未浸润浆膜层者为 5 0 .0 % ,浸润浆膜层者为 95 .5 % (P<0 .0 5 ) ;有淋巴结转移者为82 .8% ,无淋巴结转移者为 5 4.5 % (P<0 .0 5 ) ;伴有远处转移者为 10 0 % ,不伴有远处转移者为 71.0 % (P<0 .0 5 ) ;pTNM分期属Ⅰ、Ⅱ期者为 5 3 .1% ,Ⅲ、Ⅳ期者为 89.6% (P<0 .0 5 )。胃良性病变的MVD显著低于胃癌组 (P<0 .0 0 1) ;浸润深度达浆膜层、有淋巴结转移和远处转移及 pTNM属Ⅲ、Ⅳ期者的MVD显著升高 ,其差异有显著性意义。VEGF表达与MVD明显相关。

Objective To investigate the relationship of vascular endothelial growth factor (VEGF), microvessel density (MVD) and progression of gastric carcinoma (GC). Methods The expression of VEGF and MVD in archival wax embedded specimens of 80 cases of GC and 20 gastric benign disease (GBD) were examined by using immunohistochemical staining. Results The positive expression rate (PER) of VEGF in GC was 75.0%, and in GBD 5.0% ( P < 0.05) . The PER of VEGF in GC with invasive serosa was 95.5%, in those without serosal invasion 50.0% ( P <0.05). 82.8% was the PER of VEGF in GC with lymph node metastasis, 54.5% without lymph node metastasis ( P <0.05).The PER of VEGF in GC accompanied by distant metastasis was 100%, higher than that without distant metastasis (71.0%, P <0.05). PER of VEGF in pTNM Ⅰ+Ⅱ was 53.1%, in Ⅲ+Ⅳ 89.6% ( P <0.05). MVD correlated significantly with depth of invasion, lymph node metastasis,distant metastasis and pTNM stages ( P <0.05). There was correlationship between MVD and VEGF ( P <0.05).Conclusion VEGF expression up regulation and MVD contribute to the progression of gastric carcinoma.