急性氟乙酰胺中毒患者β_2-微球蛋白含量变化及临床意义

The changes and clinical meaning of β_2-MG in the patients with acute fluoroacetamide poisoning

目的 :探讨β2 -微球蛋白 (β2 - MG)在急性氟乙酰胺中毒中的变化及其意义。方法 :用放射免疫分析法测定6 8例急性氟乙酰胺中毒患者第 1、2、3、5、7、10天血清及尿β2 - MG的含量。结果 :治疗组与对照组 (30例 )比较有显著性差异 P<0 .0 5 ,重度组与对照组比较有非常显著差异 (P<0 .0 1)。结论 :急性氟乙酰胺中毒患者血清及尿β2 - MG升高越显著 ,中毒程度越重 ,预后越差。

Objective:In order to study the changes and the meanings of β2-MG in the patients with acute fuloroacetamide poisoning.Methods:The β2-MG contains in serum and urine from 68 cases of patients with acute fluoroacetamide poisoning were detected by radioimmune-analysis-way when the first,the second,the third,the fifth,the seventh and the tenth day.Results:There are significant difference between the treatment group and the control group (30 cases) (P<0.05).There are extraordinary remarkable difference between the group of the critical patients and the control group(P<0.01).Conclusions:The higher the contains of β2-MG in serum and urine in patients with acute fluoracetmide poisoning,the more seven the poisoning and the worse the prognosis.