萘替米星对老年肺部感染患者的临床疗效及其肺组织药物浓度研究

Clinical effect of Netilmicin on pulmonary infection in the aged and the research on its concentration in lung tissue

目的:观察萘替米星对老年肺部感染的临床疗效,研究其在肺组织中的药物浓度。方法:临床研究对象为老年肺部感染患者49例,通过观察萘替米星临床疗效,并通过TDX荧先偏振免疫分析仪测定16例肺炎患者血清及支气管肺泡灌洗液中的药物浓度,以酶偶联速率法测定尿素浓度,并计算肺泡灌洗液中萘替米星稀释倍数。结果:萘替米星对老年肺部感染临床总有效率85.71％,痊愈率67.35％;痰细菌清除率为86.11％;低浓度lmg/L即对革兰氏阴性杆菌有抗菌活性,4～8mg/L可抑制菌株中60％～85％的细菌生长。结论:萘替米星每天全量给予,可获得较高的血药浓度,并在肺泡中达到高的药峰浓度,并可通过测定血清药物浓度预测肺泡药物浓度。

ve To observe the clinical effect of Netilmicin on pulmonary infection in the aged and to determine the concentration in lung tissue. Methods Forty-nine old patients with pulmonary infection were observed. Netilmicin's concentration was determined in serum and bronchoalveolar lavage fluid(BALF) with TDX fluorescence polarized immune a-nalysis instrument. The urea concentration was determined, in serum and BALF with enzyme linked rate and the diluent mul-tiple was calculated. Results Netilmicin has good clinical effect on pulmonary infection in the aged with the effective rate of 85. 71 % .curable rate of 67. 35% .clearance rate of spetum bacteria 86. 11 %. So low concentration in serum with 1mg/L has high antiseptic activity. 4~8mg/L can inhibit 60%-85% bacteria growth. Conclusions Netilmicin has high concentration in blood serum and pulmonary alveoli with once-daily dosing,and Netilmicin's concentration in pulmonary alveoli can be calculat-ed through measuring its content in serum.