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瘦素及瘦素受体与糖尿病的研究进展 被引量：2

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摘要 肥胖(Obesity Ob)是2型糖尿病(DM2)的高危因素,1994年Zhang[1]用定位克隆技术首次成功克隆小鼠的Ob基因及人类的同源序列,1995年Halaas[2]经实验证明Ob基因编码的产物是在脂肪组织中合成并分泌的一种蛋白质类激素-瘦素(leptin),该词源于希腊文"Leptos",意为"瘦的"、"单薄的",因其能降低脂肪堆积故称之为瘦素,因此,Ob基因亦称leptin基因.现将有关leptin及瘦素受体(leptin Receptor lepR)在DM2发病机制中的作用概述如下.
作者 苏 永 汪艳芳 李德霞
机构地区 河南省人民医院二内科
出处 《河南诊断与治疗杂志》 2002年第3期180-182,共3页 Henan Journal of Diagnosis and Therapy
关键词 瘦素 瘦素受体 糖尿病 LEPTIN基因 肥胖
分类号 R587.1 [医药卫生—内分泌]
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参考文献10

  • 1Wu桺eng XS,Chua SC,Jraru SH,et al.Phenotype of the obese Ko-letsky(f) rat due to tyr 763 stop mutation in the extracellular domain of the ieptin receptor. Diabetes . 1997
  • 2Considine RV.Serum immunore active-Leptin concentrations in normal weight and obese human[].The New England Journal of Medicine.1996
  • 3Kieffer TJ,Heller RS,Leech CA,et al.Leptin suppression of insulin secretion of ATP ?sensitive K + channals in pancreatic beta-cells (J)[].Diabetes.1997
  • 4Considine RV,Sinha MK,Heiman ML,et al.Surum immunoreactive -leptin concentratinns in normal-weight and obese humans[].The New England Journal of Medicine.1996
  • 5Halaas.Weight-reducing ehects of the plasma protein encoded by the obese gene[].Science.1995
  • 6Sinha MK.Evidence of free and bound leplin in human circulation studies in lean and obese subjects and during short-Rerne fasting[].The Journal of Clinical Investigation.1996
  • 7Widjaja A,Strattom IM,Horm R,et al.Plasma leptin obesity and plasma insulin in type 2 diabetic subjects[].The Journal of Clinical Endocrinology.1997
  • 8Issen O,Gaway N,Tamura N,et al.Structural organization and chro-mosomal assignment of the human obese gene[].Journal of Biological Chemistry.1995
  • 9Thompson DB,Ravussine,Bennet PH,et al.Structure and sequence variation at the human leptin receptor gene in lean and obese pima In-dians[].Human Molecular Genetics.1997
  • 10Masuzakih O,Gaway N,Zssen N,et al.Human obese gene expres-sion.Adipocyte-specific expression and regional differences in the adi-pose tissue[].Diabetes.1995

同被引文献9

  • 1Fajans SS, Bell GI, Polonsky K S. Molecular mechanisms and clinical pathophysiology of maturity - onset diabetes of the young. N Engl J Med, 2001, 345:971.
  • 2Shimomura H, Sanke T, Hanabusa T, et al. Nonsense mutationof islet-1 gene (Q310x) found in a type 2 diabetic patient with a strong family history [J]. Diabetes, 2000, 49:1597.
  • 3Bingham C, Bulman MP, Ellard S, et al. Mutations in the hepatocyte nuclear factor - 1/3 gene are associated with familial hypoplastic glomrulocystic kidney disease. Am J Hum Genet,2001, 68:219.
  • 4American Diabetes Asscoiation. Report of the expert committeeon the diagnosis and classification of diabetes mellitus. Diabetes Care, 1997, 20:1183.
  • 5Lindner TH, Njolstad PR, Horikawa Y, et al. A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo - POU domain of hepatocyte nuclear factor - 1/β[J]. Hum Mol Genet, 1998,8:2002.
  • 6Iwasaki N, Okabe I, Momoi M Y, et al. Splice site mutation in the hepatocyte nuclear factor -1β gene, IVS2nt + IG＞A,associated with maturity - onset diabetes of the young, renal dysplasia and bicornuate uterus . Diabetologia, 2001, 44:387.
  • 7McNeely MJ, Boyko EJ, Weigle DS, et al. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care,1999,22:65-70.
  • 8张政祥,李红辉,陈家林,向阳,洪锐东,刘延柏,李晟.血清瘦素与原发性高血压和体脂及血脂的关系研究[J].高血压杂志,2002,10(2):110-113. 被引量：18
  • 9翁秀妹,于澎,何世元.中老年2型糖尿病患者血清瘦素水平分析[J].上海医学检验杂志,2003,18(4):219-220. 被引量：2

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河南诊断与治疗杂志
2002年 第3期

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