CD44和nm23基因在滋养细胞肿瘤中的表达及临床意义

Expression of CD44and nm23gene in Gestational Trophoblastic Tumor and Its Clinical Significance

的:探讨转移促进基因CD44和转移抑制基因nm23在预测滋养细胞肿瘤转移能力方面的意义。方法:采用SP免疫组织化学法检测57例滋养细胞疾病组织蜡块的CD44v6和nm23H1的表达情况。结果:57例滋养细胞疾病的石蜡标本中,nm23H1和CD44v6表达阳性率在葡萄胎组与滋养细胞肿瘤组有显著性差异(P<0.05),CD44v6表达阳性率在恶性滋养细胞肿瘤的临床Ⅰ期和Ⅱ～Ⅲ期间有显著性差异(P<0.05)。结论:nm23H1的缺失和CD44v6过表达与滋养细胞肿瘤的恶性程度密切相关,CD44v6对预测滋养细胞肿瘤远处转移具有较高预测价值。

Objective:To detect the prediction significance of nm23H1and CD44v6in metasta sis of trophoblastic tumor.Methods:Immunohistochemical SP method was used to detect the expression of CD44v6and nm23H1in57samples of GTD paraffin tissues in57cases.Results:In this series,the positive rate of nm23H1and CD44v6had significant difference between the hydatidi form mole group and trophoblastic tumor group(P<0.05).The positive rate of CD44had sig nifi cant difference between the clinical stageⅠand clinical stageⅡ～Ⅲof trophoblastic tumor.Conclusion:The absent expression of nm23H1and the over expression of CD44v6are correlated with malignant extent of GTT,and CD44v6has high predicting evaluation in trophoblastic tumor.