软肝汤治疗慢性肝炎后肝纤维化的临床观察

Clinical Observation of "Liver-Softening Decoction" in Treating Liver Fibrosis Following Chronic Hepatitis

观察软肝汤治疗慢性肝炎后肝纤维化的临床疗效。将 6 0例患者随机分成软肝汤治疗组和人参鳖甲煎丸对照组各 30例 ,观察其对症状、体征、肝功能、肝纤维化指标的改善作用 ,疗程 6个月。结果 :治疗组对症状体征有明显改善 ,其中神疲乏力症状的改善与对照组相比有显著差异P <0 0 1。对肝功能指标G、γ 球蛋白的改善治疗前后有显著差异P <0 0 5。γ 球蛋白的改善与对照组相比也有显著差异P <0 0 1。对肝纤维化指标HA、IVC、PIIIP、LN的改善治疗前后均有显著差异P <0 0 1,与对照组相比HA、LN、IVC有显著差异P <0 0 5。总有效率治疗组为83 33%,对照组为 73 33%(P <0 0 5 ) ,治疗组显效率 33 33%对照组 2 3 33%(P <0 0 1)。提示软肝汤对治疗乙型病毒性肝炎肝纤维化、早期肝硬化有较好疗效。

To observe the clinical efficacy of 'Liver-Softening Decoction'in the treatment of liver fibrosis following chronic hepatitis,60 cases were randomized into treatment group with 30 cases treated with'Liver-Softening Decoction'and control group with another 30 cases treated with'Ginseng Trionychidae Pill'.They were all treated for 6 months.The clinical symptoms,signs,liver function and indexes related to liver fibrosis were observed.Results:In treatment group,the clinical symptoms and signs improved significantly,especially fatigue that improved more obviously in comparison with control group,P<0.01;globulins and γ-globulins improved obviously after treatment,P<0.01,also improved much more in comparison with control group,P<0.01;HA,IVC,PIIIP and LN also improved remarkably after treatment,P<0.01,with a significant difference of HA,LN (P<0.01)and IVC (P<0.05)in comparison with control group;the total effective rates were 83.33% and 73.33% respectively in treatment group and control group,with a difference between them,P<0.05;the excellent rates were 33.33% and 23.33% respectively,with a significant difference between them,P<0.01.It is indicated that'Liver-Softening Decoction'has a better effect on liver fibrosis and cirrhosis arising from virus B hepatitis.