盐酸米多君的合成

Synthesis of Midodrine Hydrochloride

以对苯二酚为原料 ,经酯化、重排、醚化、溴代、胺化、酰胺化、叠氮化、硼氢化钾 /钯炭还原等 8步反应合成盐酸米多君。还原反应改用成本较低的硼氢化钾 ,操作简单 ,条件温和。总收率 15 .1%。

Midodrine Hydrochloride was synthesized from hydroquinone by esterification, rearrangement, etherification, bromination, amination, amidation, azidation and reduction with an overall yield of 15.1%.