羟萘甲酸沙美特罗中有机溶剂残留量的气相色谱法测定

Determination of Residual Organic Solvents in Salmeterol Xinafoate by Capillary Gas Chromatography

采用毛细管气相色谱法 ,以外标法测定羟萘甲酸沙美特罗中乙醚、乙醇、异丙醇、乙酸乙酯、四氢呋喃、氯仿和甲苯的含量 ,用串联的 HP- 1(0 .5 3m m× 30 m )和 HP- FFAP(0 .5 3m m× 30 m)色谱柱 ,柱温采取程序升温的方法。在本色谱条件下 ,测得各组分的线性关系良好 (相关系数均在 0 .998以上 ) ;7种溶剂的平均回收率为 89.1%～10 2 .7% ,RSD 2 .9%～ 5 .2 % ,最小检出量为 0 .0 74～ 0 .6

A simple capillary gas chromatography method was established for the determination of residual ethoxyethane, ethanol, isopropanol, ethyl acetate, tetrahydrofuran, chloroform and toluene in salmeterol xinafoate. The linearities were fairly good. The limit of detection was 0.074~0.63 ng. The recovery was 89.1%~102.7% with RSD of 2.9%～5.2%.