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盐酸班布特罗的HPLC测定 被引量:3

Determination of Bambuterol Hydrochloride by HPLC
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摘要 采用 HPL C测定盐酸班布特罗的含量。以十八烷基硅烷键合硅胶为固定相 ,以 6 .0 m mol/L辛烷磺酸钠的甲醇溶液 -乙腈 - 5 0 mm ol/L磷酸盐缓冲液 (p H 3.0 ) (34∶ 11∶ 35 )为流动相 ,检测波长 2 14 nm。 A HPLC method of the determination of bambuterol hydrochloride was established. A C 18 column was used, with the mobile phase of 6.0 mol/L sodium octyl sulfate methanol solution acetonitrile 50 mmol/L phosphate buffer (pH 3.0)(34∶11∶55), at the detection wavelength of 214 nm. p Ace tamidoanisol was used as the internal standard.
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2002年第5期245-246,共2页 Chinese Journal of Pharmaceuticals
关键词 盐酸班布特罗 对乙酰氨基苯甲醚 HPLC 内标法 测定 bambuterol hydrochloride p acetamidoanisol HPLC method of internal standard determination
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  • 1Olsson OA,Sevensson LA,Wetterlin KIL.1-(Dihydroxyphenyl)-2-amino-ethanol derivatives;preparation,compositions and intermediates[P].EP:0043807,1983-12-06.(CA 1996,125:199263y)
  • 2Olsson OA,Svensson LA,Wetterlin KIL.Carbamate intermediates for bronchospasmolytics[P].US:4451663,1982-07-06.(CA 1982,96:199263)
  • 3Svensson LA.Bambuterol--a prodrug-prodrug with built-in hydrolysis brake[J].Acta Pharm Suec,1987,24:333-341.
  • 4Wannerberg O,Persson B.Liquid chromatographic method for the determination of bambuterol hydrochloride and related compounds[J].J Chromatogr,1988,435:199-203.

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