摘要
目的 :探讨复方紫归胶囊对更年期综合征大鼠的防治作用 ,为临床应用提供理论依据。方法 :采用去势大鼠作为模型 ,观察复方紫归胶囊对去势大鼠体重和脏器系数的影响 ;用核医学单光子发射型计算机断层仪 (SPECT)对去势大鼠进行骨代谢的测定。结果 :复方紫归胶囊能使去势大鼠增重现象消失、子宫萎缩减轻 ;可使血中雌激素含及血磷值上升 ;骨代谢测定结果显示该药能使骨代谢单位体重的放射性计数明显提高。结论 :复方紫归胶囊对去势大鼠内分泌紊乱、体重增加。
Objective: To study the protection for Compound Zigui Capsule on climacteric syndrome and the mechanism of the action, connected clinical application.Methods: Ovaritectomized rats were used as model of climacteric syndrome and to observed the effects of Compound Zigui Capsule on weight and the index of the organ of OVX rats. Bone metabolism of OVX rats was examined by single photon radionulide emission computed tomograpy.Results: Compound Zigui Capsule could antagonize an increase in body weight and atrophy of the uterus of OVX rats. The estrogenic content and phosphoric level in serum increased significantly. Results of bone metaboism examination showed that the radioactive cound/weight(c/w t) increased. Conclusion: Compound Zigui Capsule had markedly effect on improvement of endocrine disorder, increase of weight, atrophy of the sexual organs and osteopenia in OVX rats.
出处
《中成药》
CAS
CSCD
北大核心
2002年第5期366-369,共4页
Chinese Traditional Patent Medicine
基金
甘肃省医药卫生科研资助项目(No :2 0 0 0 32 2 )
