期刊文献+

细胞周期抑制剂P27^(Kip1)对乳腺癌的预后意义

下载PDF
导出
摘要 P2 7Kip1属广谱CDKI家族 ,是一种细胞周期的负向调节剂 ,在细胞增殖、分化、凋亡及肿瘤的发生发展等过程中具有重要的调节作用。人类肿瘤中P2 7基因的改变极为罕见 ,但P2 7蛋白表达的改变与其生物学行为密切相关 ,近年来的诸多研究表明P2
出处 《国外医学(生理病理科学与临床分册)》 2002年第2期110-112,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
  • 相关文献

参考文献18

  • 1Polyak K, Lee MH, Erdjument BH, et al. Cloning of P27Kip1 , a cyclindependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals [J]. Cell, 1994, 78: 59-66.
  • 2Chen J, Willingham T, Shuford M, et al. Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor P27Kip1 [J].J Clin Invest, 1996, 97:1983 - 1988.
  • 3Lloyd RV,Jin L, Qian X, et al. Aberrant P27Kip1 expression in endocrine and other tumors [J]. Am J Pathol, 1997, 150:401-407.
  • 4Kawamata N, Morosetti R, Miller CW, etal. Molecular analysis of the cyclin-dependent kinase inhibitor gene P27Kip1 in human malignancies [J]. Cmcer Res, 1995, 55: 2266-2269.
  • 5Spirin KS, Simpson JF, Takeuchi S, et al. P27Kip1 mutation found in breast cancer [J]. Cancer Res, 1996, 56:2400 - 2404.
  • 6Katayose Y, Kim M, Rakkar ANS, et al. Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor P27 [ J ].Cancer Res, 1997,57:5441-5445.
  • 7Durand B, Gao FB, Rolf M, et al. Accumulation of the cyclin-dependent kinase inhibitor P27Kip1 and the timing of oligodendrocyte differentiation [J]. EMBO J, 1997, 16: 306-317.
  • 8Muto A, Kizaki M, Yamato K, et al. 1,25-dihydroxyvitamin D3 induces differentiation of retinoic acid-resistant acute promyelocytis leukemia cell line ( UF-1 ) associated with expression of P21Waf/Cip1 and P27Kip1[J]. Blood, 1999, 93: 2225-2233.
  • 9Pagano M, Tam SW, Theodoras AM, et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor P27 [J]. Science, 1995, 269: 682-685.
  • 10Tan P, Cady B, Wanner M, et al. The cell cycle inhibitor P27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas [J]. Cancer Res, 1997, 57:1259 - 1263.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部