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PTTG——一种新的肿瘤转化基因 被引量:3

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摘要 新近报道的新型癌基因垂体肿瘤转化基因 (PTTG) ,其高表达在促进细胞增殖 。
作者 金中元
出处 《国外医学(生理病理科学与临床分册)》 2002年第2期113-115,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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  • 1Pei L, Melmed S. Isolation and characterization of a pituitary tumortransforming gene(PTTG)[J]. Mol Endocrinol, 1997, 11: 433-441.
  • 2Dominguez A, Ramos-Morales F, Romero F, et al. hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG[J]. Oncogene,1998, 17: 2187-2193.
  • 3Zhang X, Horwitz GA, Prezant TR, et al. Structure, expression, and function of human pituitary tumor-transforming gene(PTTG) [J]. Mol Endocrinol,1999, 13: 156-166.
  • 4Prezant TR, Kadioglu P, Melmed S. An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family[J]. J Clin Endocrinol Metab, 1999, 84: 1149-1152.
  • 5Chen L, Puri R, Kakar SS, et al. Identification of the human pituitary tumor transforming gene(hPTTG) family: molecular structure, expression, and chromosomal localization[J]. Gene, 2000, 248:41-50.
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  • 7Kakar SS. Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)[J]. Gene, 1999, 240:317-324.
  • 8Zhang X, Horwitz GA, Heaney AP, et al. Pituitary tumor transforming gene(PTTG) expression in pituitary adenomas[J]. J Clin Endocrinol Metab, 1999, 84:761-767.
  • 9Saez C, Japon MA, Ramos-Morales F, et al. hpttg is over-expressed in pituitary adenornas and other primary epithelial neoplasias [ J ]. Oncogene, 1999, 18: 5473-5476.
  • 10Heaney AP, Singson R, McCabe CJ, et al. Expression of pituitary-tumor transforming gene in colorectal tumors[J]. Lancet, 2000, 355:716-719.

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