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凝血酶敏感蛋白1抗血管新生作用研究进展 被引量:9

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摘要 凝血酶敏感蛋白 1(thrombospondin 1,TSP 1)是重要的多肽类内源性血管新生抑制物。TSP 1的抗血管新生活性主要由其第 2和第 3个备解素样 (type 1repeats)重复顺序承担 ;P5 3蛋白是TSP 1基因的关键转录调节因子 ;CD36分子介导的内皮细胞凋亡是TSP 1抑制血管新生作用的重要机制 ;TSP
机构地区 中国医学科学院
出处 《国外医学(生理病理科学与临床分册)》 2002年第2期122-124,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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