雌激素的膜受体机制
摘要
细胞膜存在雌激素受体的非基因组效应。 17β-雌二醇〔E2 〕胞膜受体 ,通过增加Ca2 + 内流和环核苷酸途径诱导快速信号转导过程 ,如磷酸肌醇 3-激酶系统、蛋白激酶B/AKT系统、ERK和P38MAP激酶系统转导通路。这些通路使E2 膜效应与细胞其他功能紧密衔接 ;E2 非基因组效应参与神经和血管细胞调节作用。E2 受体池假说很好地解释E2
出处
《国外医学（生理病理科学与临床分册）》
2002年第2期159-161,共3页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
参考文献22
-
1Ranzandi M, Pedram A, Greene GL, et al. Cell membrane and nuclear estrogen receptors derive from esingle transcrpt: studies of ERαandERβexpressed in CHO cells[J]. Mol Endocrinol, 1999,13:307-319.
-
2Picotto G, Vazquez G, Boland R. 17β - oestradiol increases intracellular Ca2 + in enterocytes, potential role of phospholipase C-dependent store-operated Ca2+ influx[J]. Biochem J, 1999,339:71 - 77.
-
3Kelly MJ, Lagrange AH, Wagner E, et al. Rapid effects of estrogen to modulate G protein coupled receptors via activation of protein kinase A and protein kinase C pathways[J]. Steroids, 1998,64:64-75.
-
4Baldi E, Luconi M, Muratori M, et al. A novel functional estrogen receptor on human sperm membrane interferes with progesterone effects [J]. Mol Cell Endocrinol,2000,161:31-35.
-
5Loomis AK, Thomas P. Effects of estrogens and xenoestrogens on androgen production by Atlantic croaker testes in vitro: evidence for a nongenomic action mediated by an estrogen membrane receptor [J]. Biol Reprod,2000,62:995 - 1004.
-
6Ropero A B, Fuentes E, Rovira JM, et al. Non-genomic actions of 17β- oestradiol in mouse pancreaticβ-cells are mediated by a cGMP-dependent protein kinase[J]. J Physiol, 1999,521: 397 - 407.
-
7Russell KS, Haynes MP, Sinha D, et al. Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellualar signaling [ J ]. Proc Nat Acad Sci USA. 2000,97: 5930 -5935.
-
8Razandi M, Pedram A, Levin ER, et al. Estrogen signals to the preservation of endothelial cell form and function[J]. J Biol Chem,2000,275:38540 - 38546.
-
9Valverde MA, Rojas P, Amigo J, et al. Acute activation of maxi-K+channels(hSlo)by estradiol binding to the βsubunit[J]. Science, 1999,285:1929 - 1931.
-
10Kawas C, Resnick S, Morrison A, et al. A Prospective study of estrogen replacement therapy and the risk of developing Alzheimer' s disease: the Baltimore longitudinal study of aging[J]. Neurology, 1997,48:1517 -1521.
-
1李丛丛,马运超,于兴华,李云龙.雌激素膜受体介导的非基因组效应[J].生命的化学,2005,25(6):447-449. 被引量：1
-
2梁晓欢,杨增明.雌激素的非基因组途径在哺乳动物雌性生殖过程中的作用机制[J].生物化学与生物物理进展,2010,37(6):594-599. 被引量：4
-
3崔肇春.类固醇激素作用的非基因组效应[J].生命的化学,1998,18(4):27-30.
-
4邹乾兴,罗韬.精子中孕酮的非基因组效应[J].生理科学进展,2014,45(6):475-478. 被引量：1
-
5生物化学[J].中国学术期刊文摘,2006,12(11):5-6.
-
6隋春红,徐亚维,闫岗林,李强,安英,王程.具有GPx和SOD双酶活性含硒76肽的制备及其穿膜效应[J].吉林大学学报（理学版）,2017,55(1):168-174. 被引量：1
-
7李亚琳.北方山溪鲵精巢中性类固醇激素的免疫细胞化学研究[J].西北农业学报,2008,17(1):27-30. 被引量：1
-
8王霞,李萍,周元国,陈星云.糖皮质激素非基因组效应及其信号转导机制[J].生物化学与生物物理进展,2006,33(3):205-209. 被引量：15
-
9刁飞,陈玉霞,刘宇健.1,25-二羟维生素D_3的生物学效应[J].生命的化学,2005,25(4):275-278. 被引量：8
-
10严进,倪灿荣,何成,王成海,路长林,鲍璿,唐铁山,黄秀英,孙方臻.睫状神经营养因子对谷氨酸引起海马神经细胞内游离Ca^(2+)浓度和P53蛋白表达的作用[J].解剖学杂志,2000,23(4):295-300. 被引量：6
