雌激素的膜受体机制
摘要
细胞膜存在雌激素受体的非基因组效应。 17β-雌二醇〔E2 〕胞膜受体 ,通过增加Ca2 + 内流和环核苷酸途径诱导快速信号转导过程 ,如磷酸肌醇 3-激酶系统、蛋白激酶B/AKT系统、ERK和P38MAP激酶系统转导通路。这些通路使E2 膜效应与细胞其他功能紧密衔接 ;E2 非基因组效应参与神经和血管细胞调节作用。E2 受体池假说很好地解释E2
出处
《国外医学(生理病理科学与临床分册)》
2002年第2期159-161,共3页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
参考文献22
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