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肿瘤抑制因子PTEN蛋白在自发性高血压大鼠主动脉平滑肌中的表达 被引量：1

EXPRESSION OF TUMOR SUPPRESSOR PTEN IN THE AORTA OF SPONTANEOUSLY HYPERTENSIVE RAT
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摘要 目的 :研究 PTEN蛋白在雄性自发性高血压大鼠及 SD大鼠主动脉中的表达。方法 :取 18周龄和 2 6周龄雄性自发性高血压大鼠及同龄雄性 SD大鼠主动脉石蜡包埋切片 ,免疫组织化学观察 PTEN在主动脉平滑肌细胞中的表达。结果 :SD大鼠主动脉平滑肌细胞中存在 PTEN阳性免疫反应产物。自发性高血压大鼠主动脉平滑肌细胞也存在 PTEN阳性免疫反应产物 ,但免疫反应产物的染色强度明显低于 SD大鼠。结论 :SD大鼠主动脉平滑肌细胞PTEN高表达 ,自发性高血压大鼠主动脉平滑肌细胞 PTEN表达呈下调趋势。提示 Objectives: To study expression of PTEN in aorta of both SD rats and SHR. Methods: The aorta from both SD rats and SHR aged at 18 and 26 weeks old were sectioned. The expression of PTEN was detected by immunohistochemistry. Results: Positive immunohistochemical production was located in VSMC of aorta from both SD rats and SHR. The intensity of positive immunohistochemical production from aorta of SD rats was stronger than that from SHR. Conclusion: Expression of PTEN is high in VSMC of aorta from SD rats. However, expression of PTEN in VSMC of aorta from SHR decreases. These results imply that PTEN may play a role in VSMC remodeling of aorta of SHR.
作者 严志强 衣昕 马红萍
机构地区 南通医学院解剖教研室 南通医学院机能实验室
出处 《南通医学院学报》 2002年第2期130-131,共2页 ACTA Academiae Medicinae Nantong
关键词 PTEN蛋白 自发性高血压大鼠 主动脉 血管平滑肌细胞 免疫组化 PTEN Spontaneously Hypertensive Rat Aorta Vascular Smooth Muscle Cell Immunohistochemistry
分类号 R541.3 [医药卫生—心血管疾病]
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参考文献6

  • 1[1]Simpson L,Parsons R. PTEN: Life as a tumor suppressor[J].Experimental Cell Research,2001,264∶29.
  • 2[2]Yamada KM,Araki M. Tumor suppressor PTEN: Modulator of cell signaling,growth, migration and apoptosis[J].J Cell Scie,2001,114∶2375.
  • 3[3]Ramaswamy S, Nakamura N, Vazquez F, et al. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of phosphatidylinositol 3-kinase/Akt pathway[J].Proc Natl Acad Sci,1999,96∶2110.
  • 4[4]Nakashima N, Sharma PM, Bookstein R, et al. The tumor suppresssor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes[J].J Biol Chem,2000,275∶12889.
  • 5[5]Schwartzbauer G,Robbins J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival[J].J Biol Chem,2001,276∶35786.
  • 6[6]Weiser-Evans MC, Quinn BE, Barkard MR, et al. Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery smooth muscle cells after vascular injury[J].J Cell Physiol,2000,182∶12.

同被引文献18

  • 1Simpson L, Parsons R. PTEN: Life as a tumor suppressor. Exp Cell Res, 2001, 264 (1): 29-36.
  • 2Yamada KM, Araki M. Tumor suppressor PTEN: modulator of cell singaling, growth, migration and apoptosis. J Cell Sci, 2001, 114 (13): 2375-2382.
  • 3Tolkacheva T, Chan AM. Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene, 2000, 19 (5): 680-689.
  • 4Tamara M, Gu J, Matsumoto K, et al. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science, 1998, 280 (5369): 1614-1617.
  • 5Gu J, Tamara M, Yamada KM. Tumor suppressor PTEN inhibits integrin and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol, 1998, 143 (5):1375-1383.
  • 6Sun H, Lesche R, U DM, et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3, 4, 6, -trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA, 1999, 96 (11): 6199-6204.
  • 7Moorehead RA, Hojilla CV, De Belle I, et al. Insulin-like growth factor-Ⅱ regulates PTEN expression in the mammary gland. J Biol Chem, 2003, 278 (50): 50422-50427.
  • 8Leslie NR, Bennett D, Lindsay YE, et al. Redox regulation of PI3-kinase signalling via inactivation of PTEN. EMBO J, 2003, 22 (20): 5501-5510.
  • 9Wu RC, Li X, Schonthal AH. Transcriptional activation of p21 WAF1 by PTEN/MMAC1 tumor suppressor. Mol Cell Biochem, 2000, 203 (1-2): 59-71.
  • 10Schwartzbauer G, Robbins J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem, 2001 (38), 276: 35786-35793.

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南通医学院学报
2002年 第2期

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