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甲状腺素对心脏离子通道和转运装置的影响 被引量：2

Effect of thyroid hormones on cardiacion channels and transporters
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摘要 本文综述了甲状腺素对心脏离子通道和转运装置的作用 ,解释了其引起心肌细胞动作电位变化原因。并从分子生物学方面进行探讨 ,从而说明甲状腺素对心脏作用的机制。 In the article the effect of thyroid hormones was reviewed on cardiac ion channels and transports, so as to explain the changes of the action current on cardiac myocyte. Based on the molecular biology, the hormonal regulation of cardiac and transports were discussed and explained.
作者 方放治
机构地区 中国药科大学药理研究室
出处 《中国临床药理学与治疗学》 CAS CSCD 2002年第2期177-180,共4页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 甲状腺素 离子通道 心脏 心肌细胞 转运装置 thyroid hormones ion channels heart transporters cardiac myocyte
分类号 R966 [医药卫生—药理学]
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参考文献33

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同被引文献52

  • 1姚青海,崔长琮,李强,王军奎,姚晓伟,赵永辉.单相动作电位同步记录电极的建立和应用[J].西安交通大学学报（医学版）,2005,26(1):89-92. 被引量：15
  • 2戴德哉.心律失常,离子通道病及新药发现[J].中国临床药理学与治疗学,2006,11(9):961-965. 被引量：4
  • 3Ralph FB,Stanley N.Cellular electrophysiology of atrial fibrillation[J].Cardiovascular Research,2002,54:259-269.
  • 4Jais P,Haissaguerre M,Shah DC,et al.A focal source of atrial fibrillation treated by discrete radiofrequency ablation[J].Circulation,1997,95:572.
  • 5Sabatino L, Colantuoni A, Iervasi G. Is the vascu-lar system a main target for thyroid hormones? From molecular and biochemical findings to clinical perspectives[J]. Curr vasc Pharrnacol , 2005, 3(2): 133-145.
  • 6ChanoineJP, Braverman LE, Farwell AP, et al. The thyroid gland is a major source of circulating T3 intherat[J].JClinInvest, 1993,91(6): 2709- 2713.
  • 7Sabatino L, Chopra IJ, Tanavoli S, et al. A radio-immunoassay for type I iodothyronine 5'-monodeio-dinase in human tissues[J]. Thyroid, 2001, 11 (8) : 733-739.
  • 8Gerel.ien B,Zavacki AM, Ribich S, et al. Cellular and molecular basis of deiodinase regulated thyroid hormone signaling[J]. Endocr Rev, 2008, 29 (7) : 898-938.
  • 9Trivieri MG, Oudit GY, Sah R, et al. Cardiac- specific elevations in thyroid hormone enhance con-tractility and prevent pressure overload-induced car-diac dysfunction[J]. Proc Nat! Acad Sci USA, 2006,103(15): 6043-6048.
  • 10Liu Y, Redetzke RA, Said S, et al. Serum thyroid hormone levels may not accurately reflect thyroid tissue levels and cardiac function in mild hypothy-roidism[J]. AmJ Physiol Heart Circ Physiol . 2008, 294(5): H2137- H2143.

引证文献2

二级引证文献8

中国临床药理学与治疗学
2002年 第2期

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