高血压患者尿液多项特定蛋白与尿酶及细胞因子检测的临床价值

THE CLINICAL VALUE OF EXAMINING URINARY SPECIAL PROTEINS NAG AND CYTOKINESIN OF HYPERTENSIVES

目的 探讨尿多项特定蛋白、尿酶、细胞因子对高血压早期肾损伤的诊断价值。方法 高血压患者 5 3例 ,根据尿蛋白定性结果分为尿蛋白阴性组 (30例 )和尿蛋白阳性组 (2 3例 ) ,应用免疫比浊法、终点法及ELISA法分别检测尿mALB、TRF、Fn、IgG、RBP、β2 MG、NAG、IL 6、IL 8水平。结果 高血压患者尿蛋白定性阴性时尿各项特种蛋白、NAG皆高于正常对照组 (P <0 .0 1) ,尿蛋白阳性组以上各项指标均明显高于尿蛋白阴性组 ,尿蛋白阳性组尿IL 6、IL 8明显增高。 结论 在反映肾小球功能的指标中 ,尿TRF最为敏感 ,在反映肾小管功能的指标中 ,以RBP最敏感 ,联合检测特定蛋白、尿酶可作为早期诊断高血压肾功损伤的的灵敏指标。而IL 6、IL 8等细胞因子检测可反映肾损伤的严重程度 ,对高血压肾病发病机理的探讨。

Objective To explore the diagnostic value of urinary special proteins,NAG and cytokinesin in terms of early renal injuries in hypertensives.Methods 53 hypertensives were divided into negative group and positive group according to the results of qualitative examination of urinary proteins.The levels of urinary mALB,TRF,Fn,IgG,RBP,β 2 MG,NAG,IL 6 and IL 8 were respectively examined through immunoturbidimetry,endpoint and ELISA methods. Results The levels of urinary special proteins and NAG in the negative group were found higher than those in the control group,and the levels of them were also found higher in the positive group than in the negative group.The levels of IL 6 and IL 8 in the positive group were found comparatively high.Conclusion Urinary TRF in reflecting glomerular functions was found to be the most sensitive of all indexes,while RBP in reflecting renal tubular function was the most sensitive.The combined determination of urinary special proteins and NAG can help to early diagnose the renal functional diseases.The determination of IL 6 and IL 8 can reveal the degrees of renal injuries and so it,can help to explore the pathogenesis of nephrosis and to monitor the state of disease.