局部放置缓释强力霉素治疗慢性牙周炎68例疗效观察

THE EFFECT OF LOCAL APPLICATION OF LOW-RELEASED DOXYCYCLINE TO THE TREATMENT OF 68 CASES OF CHRONIC PERIODONTITIS

目的 探讨局部放置缓释强力霉素 (doxycyclinehyclate ,DH )治疗慢性牙周炎的临床疗效。方法 将颗粒型羟基磷灰石 ,Doxycycline和煅石膏按一定比例制成强力霉素给药系统 ,对 6 8位慢性牙周炎病人进行治疗 ,并以传统的刮治与根面平整 (Scalingandrootplaning ,SRP)作为疗效对照 ,治疗 9个月 ,评价其临床疗效。结果 9个月时 2组附着水平的获得 (DH组 0 .72mm ,S对照组 0 .75mm)和袋深的减少 (DH组 1.2 8mm ,对照组 1.13mm)结果相似。结论 DH操作简单 ,病人感觉较舒适 ,局部药物浓度高 ,作用时间长 ,可周期性使用 ,患者依从性好 ,因此DH可以单独作为慢性牙周炎维护期的治疗方法。

Objective To explore the curative effect of applying low released doxycycline in the treatment of chronic periodontitis.Methods 68 cases of chronic periodontitis were treated with the doxycycline hyclate(DH) which was made of granular hydroxyapatite ,doxycycline and calcined plaster.The curative effects were compared with those of using the traditional scaling and root planing(SRP) in the 9 month treatment period.Results Similar results were found in the two groups as to the attachment level gain(DH 0.72mm,SRP 0.75mm)and probing depth(DH 1.28mm,SRP 1.13mm).Conclusion DH can be used locally and periodically to effectively treat chronic periodontitis.