抗透明带抗体 抗精子抗体与不孕及反复自然流产的相关性研究

THE EFFECT OF ZPAb AND AsAb ON INFERTILITY AND RECURRENT SPONTANEOUS ABORTION

目的 探讨抗透明带抗体 (ZPAb)和抗精子抗体 (AsAb)对女性不孕及反复自然流产的影响。方法 对原发性不孕 4 9人 ,继发性不孕 2 9人 ,原发性自然流产 39人 ,继发性自然流产 31人 ,用ELISA方法检测其血清中AsAb和ZPAb ,与 35例健康妇女对照。结果 对照组AsAb阳性率为5 .71% (2 35 ) ,zpAb阳性率为 2 .86 % (1 35 ) ,原发性不孕组与继发性不孕组AsAb阳性率分别为30 .6 1% (15 4 9)和 2 7.5 9% (8 2 9) ,ZPAb阳性率分别为 2 4 .4 9% (12 4 9)和 2 4 .13% (7 2 9) ,与对照组比较均有显著性差异 (P <0 .0 5 )。原发性自然流产组AsAb和ZPAb阳性率分别为 2 8.2 1%(11 39)和 2 3.0 8% (9 39) ,与对照组相比有显著性差异 (P <0 .0 5 ) ;而继发性流产组中AsAb和ZPAb阳性率分别为 6 .4 5 % (2 31)和 3.2 3% (1 31) ,与对照组比较无显著性差异 (P >0 .0 5 ) ;原发性流产组与继发性流产组间AsAb和ZPAb的阳性率也有显著性差异 (P <0 .0 5 )。结论 AsAb和ZPAb在导致原发性和继发性不孕方面均有明显影响 ;对原发性流产的发生有明显作用 ,而对继发性流产的影响意义不大。检测AsAb、ZPAb可作为不孕及原发性流产病因诊断的一项指标 ,干涉其高血清浓度可望对这类疾病起到治疗作用。

Objective To study the effect of ZPAb and AsAb on female infertility and recurrent spontaneous abortion(RSA).Methods AsAb and APAb in serum were detected with ELISA in 49 cases of primary infertility,29 cases of secondary infertility,39 cases of primary spontaneous abortion and 31 cases of secondary spontaneous abortion.The detection results wre compared with those in the control group of 35 health women.Results The positive rates of AsAb ZPAb in the control group were 5.71%(2/35) and 2.86%(1/35) respectively.The positive rates of AsAb in the primary infertility group and the secondary infertility group were 30.61% (15/49) and 27.59%(8/29) respectively,while the positive rates of ZPAb in the two groups were 24.49%(12/49) and 24.13(7/29) respectively,all significantly different from those in the control group(P<0.05).The positive rates of AsAb and ZPAb in the primary spontaneous abortion group were 28.21(11/39) and 23.08%(9/39) respectively ,both significantly different from those in the control group(P<0.05),while the positive rates of AsAb and ZPAb were 6.45%(2/31) and 3.23(1/31) respectively in the secondary abortion group,not significantly different from those in the control group(P>0.05).The positive rates of AsAb and ZPAb in the primary abortion group and secondary abortion group were found to be significantly different from each other(P<0.05).Conclusion AsAb and ZPAb both contribute to primary and secondary infertility.They had obvious effect on the occurence of primary abortion,but no significant effect on that of secondary abortion.The detection of AsAb and ZPAb can help to make etilogical diagnoses,and reducing the concentrations of them can help to treat infertility and primary abortion.