两对非对映体盐和两种氨基酸在二氧化碳近临界区的溶解行为

SOLUBILITY BEHAVIOR OF FOUR DIASTEREOMERIC SALTS AND TWO AMINO ACIDS IN NEAR-CRITICAL CO_2

目的 考察酒石酸 麻黄碱、酒石酸 伪麻黄碱两对非对映体盐、dl 苯丙氨酸、dl 5 羟基 色氨酸在二氧化碳流体中的溶解行为。方法 用单通路法、HPCE法。结果 温度 2 5～ 5 0℃ ,压力 6 32～ 19 4 4MPa ,酒石酸 麻黄碱、酒石酸 伪麻黄碱、dl 苯丙氨酸、dl 5 羟基 色氨酸溶解度并不随二氧化碳密度增加而升高 ;在 6 32～ 7 78MPa ,溶解度随压力变化很大。结论 酒石酸 麻黄碱、酒石酸 伪麻黄碱两对非对映体盐的溶解度有差异 ,非对映体盐、dl 苯丙氨酸、dl 5 羟基 色氨酸溶解行为存在临界异常现象。

AIM To establish a suitable condition for extraction of phenylalanine (Phe), 5 hydr oxytryptophan (5 OH Trp) and four diastereomeric salts, (1 R ,2 S ) ephed rine (2 S ,3 S ) tartaric acid, (1 R ,2 S ) ephedrine (2 R ,3 R ) tartaric acid, (1 S ,2 S ) pseudoephedrine (2 S ,3 S ) tartaric acid, (1 S ,2 S ) pseudoephedrine (2 R ,3 R ) tartaric acid in supercritical fluid extrac tion and to assess the solubilities of Phe, 5 OH Trp and the four diastereomer ic salts in CO 2. METHODS Single pass method and HPCE. RESULTS The solubilities of Phe, 5 OH Trp and the four diastereomeric salts in CO 2 w ere determined over temperature and pressure ranges of 25～50℃ and 6 32～34 0 3 MPa respectively. The experimental results showed that the solubilities of Phe , 5 OH Trp and the four diastereomeric salts do not increase with density of C O 2. There existed a maximum in the critical region of CO 2. CONCLUSION The dramatically high solubilities in the pressure of 6 32～7 78 MPa show a cr itical behavior, which can be explained by critical characteristic through therm odynamics analysis. The results suggest that the separation of Phe, 5 OH Trp a nd the four diastereomeric salts is more efficient in critical region of CO 2.