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石杉碱甲改善中老年语词记忆障碍的临床研究 被引量:4

A Clinical Study of the Effect of Huperzine A to Improve the Ability of Verbal Recall, Retention and Repetition in Middle-aged and Elderly Patients with Dysmnesia
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摘要 目的 :观察石杉碱甲 (HupA)对不同程度中老年记忆功能障碍患者的语词记忆增强作用。方法 :5 0例中老年记忆功能障碍患者 ,采用自身交叉双盲法分别给以HupA 10 0 μg和安慰药 ,po ,bid ,每个疗程 2周。测定服药前后语词记忆能力 ,辅以脑地形图和血胆碱酯酶活力检查。结果 :轻、中度记忆功能障碍患者服用安慰药后回忆总数 (∑R)分别增加 ( 0 .91± 3.6 0 )和 ( 0 .86± 1.79)分 ,而服用HupA后分别增加 ( 6 .0 5± 2 .87)和 ( 6 .43± 2 .2 4)分 ,长时再现数 (LTR)、长时记忆数 (LTS)、恒定长时再现数 (CLTR)、未经提醒回忆数 (UrR)也相应增加 ;服用安慰药后短时再现数 (STR)分别增加( 0 .90± 3.32 )和 ( 0 .71± 2 .95 )分 ,而服用HupA后分别减少 ( 1.90± 3.78)和 ( 2 .36± 2 .6 2 )分 ,不恒定长时再现数 (RLTR)、提醒数 (Pr)和经提醒回忆数 (RR)也有类似的变化。服用安慰药后轻、中度患者 11次未通过全部语词回忆的有 2 4例 ,而服用HupA后仅有 10例。HupA使 13例患者异常脑地形图改善或转为正常。与安慰药比较 ,这些变化在统计学上有显著或极显著性。但对记忆功能严重低下者大多无明显效果。未发现HupA有严重的不良反应 ,外周血胆碱酯酶无明显抑制。结论 :HupA主要对轻。 Objective:To survey the effect of huperzine A (Hup A) to promote verbal recall in middle aged and elderly patients with dysmnesia of varying severities. Methods:50 middle aged and elderly patients with dysmnesia were given each placebo or Hup A 100μg, po, bid. for 2 weeks, according to the randomized double blind crossing medication method. Multiple selective verbal reminding tests were conducted before and after the medication. As auxiliaries, topographic mapping of the brain and determination of blood cholinesterase activity were also performed. Results:In patients with mild and moderate dysmnesia, values of Σ recall( ΣR ) were increased by 0.91±3.60 and 0.86±1.79, respectively, in those given placebo, and 6.05±2.87 and 6.43±2.24, respectively, in those given Hup A. Long term retrievel(LTR), Long term storage(LTS), Consistent LTR(CLTR) and Unreminded recall(UrR) were also increased similarly. While the values of short term recall(STR) were increased by 0.90±3.32 and 0.71±2.95, respectively, in those given placebo; they were; however; decreased by 1.90±3.78 and 2.36±2.62, respectively, in those given Hup A. Similar changes were also noticed in the values of random LTR(RLTR), presentation(Pr), reminded recall(RR) and pass number(PN). There were 24 cases given placebo and only 10 cases given Hup A who could not pass the complete verbal recall tests for 11 times. Improved or normalized topographic mapping of the brain was found in 13 patients given Hup A. All these differences are statistically significant or highly significant. In contrast, Hup A was found to have no evident effect on most patients with severe dysmnesia. No severe adverse reactions and inhibition of blood cholinesterse activity were encountered during the treatment with Hup A. Conclusion:Hup A has a fair effect to improve the ability of verbal recall, retention and repetition in patients with mild and moderate dysmnesia.
出处 《医药导报》 CAS 2002年第5期263-265,共3页 Herald of Medicine
关键词 石杉碱甲 记忆障碍 胆碱酯酶抑制药 患者 中老年 Huperzine A Dysmnesia Cholinesterase Middle aged ard elderly patients
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