三种脑神经细胞活化药治疗脑梗死的疗效比较

The Therapeutic Effects of Piracetam, NGP and CTP in the Treatment of Acute Cerebral Infarction

目的 :观察脑神经细胞活化药 (脑活化药 )吡拉西坦 (Pira)、氨基酸 低分子肽 (NGP)、三磷酸胞苷二钠(CTP)对急性脑梗死治疗的临床疗效。方法 :随机分治疗组 15 0例和对照组 5 0例。治疗组分为Ⅰ、Ⅱ、Ⅲ组 ,分别用(Pira) 8.0g·d 1 、NGP 40mg·d 1 、CTP 80mg·d 1 治疗 1个疗程 ( 15d) ,起病 1周内开始用药。于用药当天和用药结束时 ,对患者进行神经功能缺损评分及临床疗效评定。对照组选择没有运用脑活化药的病例 ,于用药第 7,15天进行临床疗效评定。结果 :脑活化药治疗组治疗前后神经功能缺损评分显著性降低 (P <0 .0 5 ) ,有效率和总进步率都显著高于对照组(P <0 .0 5 )。结论 :Pira、NGP、CTP单独运用对急性脑梗死治疗均有一定的临床疗效。

Objective:To survey the clinical therapeutic effects of piracetam(Pira), nerve growth peptide(NGP) and dinatril cytridini triphosphatis(CTP) in the treatment of acute cerebral infarction, so as to provide further theoretical basis for the clinical application of these remedies. Methods:Patients with acute cerebral infaction were divided into the treatment group and control group, with 50 cases in each. Patients in the treatment group were treated alone with Pira (8.0 g·d 1 ), NGP(40 mg·d 1 ) or CTP(80 mg·d 1 ) separately in a course of 15 days. The treatment began within a week after the onset of the disease. Scoring of nervous function disorders and assessment of the clinical therapeutic effectiveness were carried out at the beginning and termination of the medication. Patients of the control group were those who had not been given medicines capable of activating nerve cells of the brain. Assessment of the clinical effectiveness in patients of the control group was made on the 7 th and 15 th day of the treatment. Results:The sores of nervous function disorders in patients of the treatment group were significaully decreased after the treatment as compared with those before the treatment (P<0.05). The effective rate and the total improvement rate in patients treated with Pira, NGP or CTP were markedly higher than those in patients of the control group (P<0.05). Conclusion:Pira, NGP or CTP used alone may show a fair clinical therapeutic effect in the treatment of acute cerebral infarction.