潘托拉唑治疗消化性溃疡并出血36例

Pantoprazole in the Treatment of Peptic Ulcer Complicated by Bleeding

目的 :观察潘托拉唑治疗消化性溃疡并出血的疗效及安全性。方法 :采取随机分组 ,将 6 9例确诊为消化性溃疡并出血患者分为治疗组 36例 ,用潘托拉唑 40mg加入 0 .9%氯化钠溶液 10 0mL中静脉滴注 ,qd ;对照组 33例 ,用奥美拉唑 40mg加入 0 .9%氯化钠溶液中静脉滴注 ,qd ,疗程 3～ 4d。结果 :治疗组有效率 97.2 2 % ,对照组 96 .96 % ,两组差异无显著性 (P >0 .0 5 ) ;不良反应轻微。结论 :潘托拉唑治疗消化性溃疡并出血疗效确切 ,短期应用无明显不良反应。

Objective:To survey the therapeutic effect and safty rate of pantoprazole in the treatment of peptic ulcer complicated by bleeding. Methods:69 patients with confirmed diagnosis of peptic ulcer complicated by bleeding were randomly divided into the treatment group (36 cases) and control group (33 cases). To each patient of the treatment group, 40 mg of pantoprazole in 100 mL of 0.9% sodium chloride solution were given by intravenous drip q.d. Except that omerazole was used instead of pantoprazole, the treatment for patients in the control group was just the same as that in the treatment group. The course of treatment in both group lasted 3～4 days. Results:The effective rate in patients of the treatment group was 97.22%, and that of the control group, 96.96%. The difference was insignificent (P>0.05). Only mild adverse reactions were encountered in the treatment with pantoprazole. Conclusion:Pantoprazole has a definite therapeutic effect in the treatment of peplic ulcer complicated by bleeding, with little adverse reactions in short term application.