期刊文献+

肿瘤抗原MAGE-A家族成员进化关系的初步研究 被引量:3

Study on the evolutional reIationship among the member of MAGE-A family
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摘要 目的:探讨肿瘤抗原MAGE-A家族成员间的同源性,发现公共CTL表位对抗肿瘤逃逸。方法:采用1999DNNAstar软件Windwow95/98平台支持下的蛋白质核酸序列编辑、分析工具对MAGE-A家族成员进行开放阅读框、蛋白及其CTL序列同源性分析井构建种系发生树。结果:表明MAGE-A家族核苷酸同源性高达57.6%-98.0%,种系发生树显示各成员来源于同一祖先井在不同时间分野,且部分CIL表位高度相似。结论:MAGE-A 家族成员来自于同一祖先的同一家族,在肿瘤细胞中表达存在异质性,故此研究结果将有利于在发展肿瘤治疗性细胞免疫疫苗中选择合适的CTL表位。 Abstract Objective:To explore homology in mage-A family and find some common epitopes recognized by cytotoxic T lymphocyte(CTL) to oppose tumor escape.Methods:The amino acid sequence,differents open reading frame(ORF) and the known CTL epitope of themember of MAGE-A family,were analyzed using DNAstar software, and phylogenetic tree is also constructed. Results: MAGE-A family shareidentity nucleotide 57.6% - 98.0%,the phylogenetic tree showed that they are derived from a common ancestor at different time, as well asfound some CTL epitopes high similarity. Conclusion: MAGE-A family come from common an ancestor, but they bave many differences in thepattern of expression in tumor.This study can help to find the best CTL epitope vaccine to cure tumor.
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2002年第5期341-344,共4页 Chinese Journal of Immunology
关键词 MAGE-A家族 序列比较 种系发生树 肿瘤抗原 肿瘤免疫学 Keywords: MAGE-A family Sequence comparison Phylogenetic tree
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参考文献10

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二级参考文献3

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共引文献10

同被引文献28

  • 1马全,甑林林,范萍,查小明,郑伟,武正炎.MAGE-A3抗原肽负载树突状细胞诱导乳腺癌患者免疫应答的研究[J].中国现代医学杂志,2004,14(24):54-56. 被引量:11
  • 2甄林林,马全,武正炎,王萱仪.黑色素瘤抗原基因在乳腺癌中的表达及临床意义[J].南京医科大学学报(自然科学版),2005,25(12):934-935. 被引量:2
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