PCNA、P21、P53在胃癌中的表达及其意义

Expression and clinical implication of PCNA,P21,P53 in human gastric cancer

目的 :研究PCNA、P2 1、P5 3在胃癌组织中的表达及其与临床病理因素的关系。方法 :应用免疫组化S P法检测 4 6例胃癌根治术标本中PCNA、P2 1、P5 3的表达情况 ,并与临床病理资料对比研究。结果 :4 6例胃癌PCNA、P2 1、P5 3表达阳性率分别是 80 .4 %、5 6 .5 %、4 5 .7% ,其中进展期胃癌P2 1的表达率 (6 2 .9% )明显高于早期胃癌 (36 .4 % ) ,三者与胃癌的组织学类型及分级无关。PCNA的表达与胃癌浸润深度和转移有关 ;P2 1表达与胃癌淋巴结和远处转移有关 ,而与浸润深度无关 ;P5 3的阳性表达与临床病理指标无明显相关 ;PCNA与P2 1、P5 3的表达有明显的协同性。结论 :PCNA与P2 1、P5 3表达可能与胃癌的发生、发展有关 。

Objective:To study the relationship between the expression of PCNA,P21,P53 and the clinical pathological characteristics in human gastric cancer.Methods:The expressions of PCNA,P21,P53 protein were examined by S P immunohistochemical technique in 46 cases of human gastric carcinoma.Results:The positive expression rate of PCNA,P21,P53 in gastric cancer was 80.4%,56.5%,45.7%,respectively.The expressions of the 3 kinds of proteins were not correlated with the histological type and differentiation.The expression rate of P21 in advanced gastric cancer(62.9%) was significantly higher than that in early stage gastric cancer(36.4%).The expression of PCNA was correlated with invasive depth and metastasis.The expression of P21 was correlated with lymph nodes and distal metastasis,whereas,it was not correlated with the invasive depth.The P53 protein expression was not correlated with the clinical pathological characteristics.The expression of PCNA cooperated with the those of P21 and P53.Conclusion:The expressions of PCNA,P21,P53 proteins might be related to the carcinogenesis and development of gastric cancer.The 3 kinds of genic proteins are good indicators for evaluating the biological characteristics of gastric cancer.