纳络酮对小鼠有机磷农药中毒治疗作用的观察

Experimental Study of the Therapeutic Effects of Naloxone Acute Organic Phosphorous Possoning in Mice

目的:观察纳络酮在小鼠急性有机磷农药中毒抢救中的作用。方法:60只健康小白鼠随机分为三组,A组腹腔注射生理盐水(0.5ml/只);B组腹腔注射阿托品(0.3ml/只)和解磷定(0.1ml/只);C组腹腔注射阿托品(0.3ml/只)、解磷定(0.1ml/只)和纳络酮(0.03ml/只))。三组小鼠腹腔注射后分别用敌敌畏灌胃,使之中毒,并计数其死亡数。结果:A组小鼠均死亡。B组小鼠死亡8只,存活12只。C组小鼠死亡2只,存活18只。B组、C组经统计学分析,有显著性差异(P<0.05)。结论:纳络酮治疗急性有机磷农药中毒,可改善心肺功能,减少并发症,降低死亡率,且使用安全。

To investigate therapeutic effects of naloxone on acute organic phosphorous possoning in mice. Methods: Sixty healthy mice were randomly divided into 3 groups, group A (control), group B (abdominsl injected atropine 1.5ml/100g and pralidoxime 0.5ml/100g) and group C (abdominal injected atrapine 1.5ml/100g, pralidoxime 0.5ml/100g, naloxine 0.15/100g) .The three groups were given D. D. V. through gastric canal after abdominal inject. Results: All mice were death in group A, 8 mice were death in group B and only 2 mice were death in group C. The survival rate of group B and C were marked difference (P < 0.05) . Conclusions: Naloxone can improve the function of hearts and lungs, and can reduce the death rate of acute organic phosphorous poisoning in experiment.