益气温阳护卫汤对哮喘豚鼠外周血白细胞糖皮质激素受体的影响

Effects of Yiqiwenyanghuwei Decoction on the Glucocorticoid Receptor in Peripheral White Blood Cells in Asthmatic Guinea Pigs

观察益气温阳护卫汤对哮喘豚鼠外周血白细胞糖皮质激素受体 (GCR)特异性结合位点的影响。结果 :哮喘组外周血白细胞GCR水平明显降低 ;地塞米松组最低 ,与其他各组比较有显著性差异 (P <0 0 5 )。益气温阳护卫汤不同剂量组均能提高GCR特异性结合位点。结论 :益气温阳护卫汤可以提高GCR特异性结合位点 。

Effects of Yiqiwenyanghuwei Decoction (YD) on the specific binding sites of glucocorticoid receptor (GCR) in the peripheral white blood cells were studied in asthmatic guinea pigs. The guinea pigs were randomly divided into the groups of normal control (NC), asthmatic model (AM), dexamethasone treatment (DT), Yupingfeng Powder treatment (YPT), small dosage Yiqiwenyanghuwei Decoction treatment (SYDT), middle dosage Yiqiwenyanghuwei Decoction treatment (MYDT), and large dosage Yiqiwenyanghuwei Decoction treatment (LYDT). The results showed that the level of the specific binding sites of the peripheral blood GCR in the NC group were 3258 4±1070 4 sites/cell ( P <0 05); those in the AM group, 1541.1±558.9; those in the DT group, 1086 2±517 3 ( P <0 05); there was no significant difference ( P >0 05) between those in the AM group and those in the YPT (1629 9±579 1) group; all dosages of Yiqiwenyanghuwei Decoction could increase the specific binding sites of GCR, and although there was no significant difference ( P >0 05) between those in the LYDT group (2674 8±890 5) and those in the MYDT group (2481 9±974 7), there was a significant difference ( P <0 05) between those in the LYDT group and those in the SYDT group (1972 1±756).