银杏叶提取物对糖耐量减退患者胰岛素敏感性的干预作用

The Intervening Effect of GBE on Insulin Sensitivity of Patients with Glucose Tolerance Decreament

观察银杏叶提取物 (Ginkgo biloba extract,GBE)对糖耐量减退 (IGT)患者胰岛素敏感性的干预作用。选符合诊断标准的糖耐量减退患者 6 4例 ,随机分为两组。在基础治疗相同的情况下 ,治疗组 34例加用银杏叶提取物 (舒血宁 )治疗 ,对照组未加用银杏叶提取物。结果 :治疗组治愈 9例 ,有效 16例 ,无效 9例 ,总有效率为 73.5 % (95 %的可信区间为 5 8.7%～88.3% ) ;对照组治愈 2例 ,有效 5例 ,无效 2 3例 ,总有效率为 2 3.3% (95 %的可信区间为 8.2 %～ 38.4% ) ,治疗组综合疗效明显优于对照组 (χ2 =16 .15 46 ,P<0 .0 1)。治疗组治疗后餐后 2 h血糖、空腹及餐后 2 h胰岛素及 TG、L DL、U AER均显著下降 (P<0 .0 5～ 0 .0 1) ,HDL、SIS明显升高 (P<0 .0 5 ) ,而对照组治疗后上述指标无改变 (P>0 .0 5 ) ,两组治疗后上述参数比较具有显著差异 (P<0 .0 5～ 0 .0 1)。治疗组较对照组无效患者的发生危险性明显降低 (OR=0 .11,95 % CI=0 .0 4～ 0 .34 ) ;治疗组每治疗 2人 ,可较对照组减少 1例无效患者 (NNT=2 ,95 % CI=1.3～ 3.9)

Objective:To observe the effect of GBE on insulin sensitivity of patients with glucose tolerance decreament,64 cases patients were randomly divided into two groups.The treatment group was treated with GBE,but the control group was not.Result:In the treatment group,9 cases were cured,16 cases were effective,9 cases were ineffective and the total effective rate was 73.5%( 95% CI=58.7%-88 3%);In the control group,2 cases were cured,5 cases were effective,23 cases were ineffective and the total effective rate was 23.3%(95% CI=8.2%-38.4%).The difference between the two groups was significant(χ 2=16.1546,P<0 01).In the treatment group,many indexes such as TG,LDL UAER,fasting insulin decreased (P<0.05-0.01).HDL and ISI increased (P<0 05). While in the control group,these indexes had no change(P>0 05).The danger of occurrence of ineffective case in the treatment group decreased(OR=0.11,95% CI=0.04-0 34).The ineffective case in the treatment group was one case less than that in the control group every 2 cases(NNT=2,95%CI=1 3-3 9).