CD44v6和C-erbB-2在子宫内膜腺癌的表达及临床意义

Expression of CD44v6 and C-erbB-2 in Endometral Adenocarcinoma and Its Clinical Significance

目的 :探讨 CD44v6和 C- erb B- 2表达与子宫内膜腺癌侵袭和转移的关系。方法 :应用 CSA(催化信号放大系统 )免疫组化方法 ,对 50例原发性子宫内膜腺癌组织进行了 CD44v6和 C- erb B- 2检测。结果 :CD44v6和 C- erb B- 2在子宫内膜腺癌中阳性率分别为 70 .0 %和 58.0 %。 CD44v6和 C- erb B- 2表达与子宫内膜腺癌的分级、分期和转移相关 (P<0 .0 5)。结论 :CD44v6和 C- erb B- 2表达对判断子宫内膜腺癌的恶性程度。

Objective:To investigate the relationship between the expression of CD44v6 and C erbB 2 carcinogenesis,progression and metastasis of endometral carcinoma.Methods:The expression of CD44v6 and C erbB 2 in 50 cases of endometral adenocarcinoma was detected by catalyzed signal amplification (CSA) immunohistochemical technique.Results:The positive rate of CD44v6 and C erbB 2 was 70.0% and 58.0%,respectivly.CD44v6 and C erbB 2 were correlated with the histologic grading and clinical staging of endometral adenocarcinoma and correlated with metastasis ( P <0.05).Conclusions:These findings demonstrate that the positive expression of CD44v6 and C erbB 2 in endometral adenocarcinoma is useful mark to evaluate the degree of malignancy and biological behavior for tumors,and it can also predict the prognosis of patients.