可溶性CD40配体与急性冠状动脉综合征的关系

The Relation of Soluble Serum CD40 Ligand Level and Acute Coronary Syndrome

观察急性冠状动脉综合征、稳定型冠心病患者可溶性CD4 0配体变化及其与血脂水平的关系 ,采用酶联免疫吸附法测定血清可溶性CD4 0配体浓度。结果发现急性冠状动脉综合征患者可溶性CD4 0配体水平 (3.17± 2 .84 μg L)显著高于正常对照者 (1.19± 1.0 5 μg L ,P <0 .0 1)和稳定型冠心病患者 (1.6 1± 1.4 6 μg L ,P <0 .0 5 )。可溶性CD4 0配体水平受甘油三酯 (r=0 .2 3,P <0 .0 5 )、载脂蛋白B(r=0 .2 4 8,P <0 .0 5 )及高密度脂蛋白胆固醇等因素的影响 (r=- 0 .2 5 3,P <0 .0 5 )。以上提示可溶性CD4 0配体水平的升高可能与急性冠状动脉综合征的发生有关 。

Aim To investigate the sCD40L levels in acute coronary syndrome and stable coronary heart disease and its relationship with serum lipids. Methods Enzyme linked Immunosorbent Assay (ELIA) was used to measure the serum soluble CD40 ligand (sCD40L). Results sCD40L level was significantly higher in patients with acute coronary syndrome (3.17±2.84 μg/L) than in control (1.19±1.05 μg/L, P<0.01) and in stable coronary heart disease patients (1.61±1.46 μg/L, P<0.05). Soluble CD40L level was significantly related to TG (r=0.23, P<0.05), apoB (r=0.248, P<0.05), and HDLC (r=-0.253, P<0.05). Conclusions This study showed that sCD40L level was elevated in ACS, suggesting the possible relation of CD40L to the pathogenesis of ACS and it may save as a potential marker of plaque stability.