血清β-羟丁酸测定在糖尿病患者中的临床意义

CLINICAL SIGNIFICANCE OF THE DETERMINATION OF SERUM β-HYDROXYBUTYRATE IN DIABETICS

目的 :探讨血清β-羟丁酸测定在糖尿病及酮症酸中毒患者中的临床意义。方法 :采用酶速率法测定40例正常人、45例糖尿病人和 1 5例酮症酸中毒患者血清中的β-羟丁酸含量 ,同时用酮体粉对血酮体定性检测。结果 :血清β-羟丁酸在糖尿病患者中明显升高 ,升高程度与病情相关 ,酮症酸中毒患者高于无酮症糖尿病患者 ( t=9.81 ,P<0 .0 0 1 )。在无酮症糖尿病患者中 β-羟丁酸阳性率高于酮体定性阳性率。结论 :β-羟丁酸测定对于糖尿病患者病情监测、酮症酸中毒的早期诊断及预防病情恶化等方面具有重要临床意义。

Objective:To study clinical significance of serum β hydroxybutyrate in diabetes and diabetic ketoacidosis.Methods:The level of serum β hydroxybutyrate was measured in 40 normal subjects,45 cases with diabetes and 15 cases with diabetic ketoacidosis by kinetic enzymatic method and acetone bodies were determined qualitatively by acetone bodies powder.Results:Compared with that in control group,the level of serum β hydroxybutyrate was significantly high in diabetics,and was higher in the patients with diabetic ketoacidosis than in diabetics without ketoacidosis( t =9 81, P <0 001).The positive rate of β hydroxybutyrate was higher than that of quantitative acetone bodies in diabetics without ketoacidosis.Conclusion:The measurement of β hydroxybutyrate is important for monitoration of diabetes,early diagnosis of ketoacidosis,and prevention of depravation.