婴儿肝炎综合征巨细胞病毒感染的研究

A study on HCMV infection in infantile hepatitis syndrome

目的 :探讨人巨细胞病毒 (HCMV)在婴儿肝炎综合征中的病因学地位。方法 :5 2例以黄疸、肝肿大和血清转氨酶 (ALT)升高为主要临床表现的婴儿肝炎综合征患儿为观察组 ,5 0例无黄疸、肝肿大和ALT升高的肺炎、败血症和腹泻病患儿为对照组 ,测定血清HCMV -IgG、IgM (ELISA法 )和HCMV -DNA (PCR法 ) ,进行组间比较。结果 :观察组血清IgG、IgM和DNA的阳性率都高于对照组 ,分别是 :IgG73%和 5 0 % (P <0 0 5 )。IgM 40 %和 4% (P <0 0 0 1)、DNA 44 %和 2 4%。结论 :HCMV是婴儿肝炎综合征的重要致病因子 ,HCMV肝炎约占婴儿肝炎综合征的 40

Objective:To investigate the etiological role of human cytomegalovirus(HCMV)infection in infantile hepatitis syndrome.Methods:Blood samples of 52 infants with jaundice,hepamegaly and elevated serum alanine aminotransferase(ALT) were assessed for HCMV-IgG,IgM by ELISA and HCMV-DNA by PCR.The other 50 infantile patients with lobular pneumonia or sepsis or diarrhea without jaundice,hepatomegaly or elevated ALT were the control group.Results:The positive rates of serum IgG,IgM and DNA were significantly different between the hepatitis group and the control one,correspondly IgG 73% vs 50%(P<0.05),IgM40% vs 4%(P<0.001)and DNA 44% vs 24%(P<0.05).Conclusion:The results sugest that HCMV is an importent pathogen of infantile hepatitis syndrome and as high as 40% infantile hepatitis is caused by HCMV infection.