电针对大鼠神经痛痛敏分数的影响

Effects of Electroacupuncture on Hyperalgesia Score of Neuropathic Pain Rats

目的 :从单次电针实验和多次电针实验两方面 ,观察电针对神经痛大鼠痛敏分数的影响。方法 :采用轻微结扎一侧大鼠坐骨神经的神经痛模型 ,以光热辐射引起的大鼠双下肢抬脚潜伏期的差值作为神经痛的指标 (痛敏分数 )。结果 :即刻电针可明显减小神经痛大鼠的痛敏分数绝对值 ,随着电针次数的增加 ,大鼠痛敏分数绝对值逐渐恢复 ,呈现出累积效应。结论 :电针对神经痛大鼠具有显著的镇痛作用 。

Objective:To observe the effect of single electroacupuncture (EA) treatment and multiple EA treatment on hyperalgesia score of neuropathic pain in the rat. Methods:SD rat CCI (chronic constriction injury) hyperalgesia model was used as the neuropathic pain model, and hyperalgesia score employed as the sign of neuropathic pain. In single EA treatment experiments, 12 hyperalgesia rats were randomly divided into control group and EA group, while in multiple EA treatment experiments, 20 hyperalgesia rats were randomly divided into control and EA groups. Results: ① Before single EA treatment, the basal hyperalgesia scores of control group and EA group were -3.035±0.222 and -2.870± 0.332 respectively, having no significant difference between them. Following single EA stimulation, the absolute values of the hyperalgesia score decreased significantly from 20 min to 60 min after EA in comparison with control group (P<0.05). ② In multiple EA treatment experiments, the basal hyperalgesia scores of EA group and control group were -2.030±0.170 and -2.239±0.268, showing no significant difference between them. Along with increase of EA times, the absolute values of the hyperalgesia score decreased gradually. On the 12th, 14th, 21st, 24th, 26th and 28th day, the hyperalgesia scores were significantly lower than those of control group (P<0.05) and those of the 3rd week (21st～28th day after operation) were even more evidently than those of the first two weeks (P<0.05). Results showed that multiple EA treatments had an obviously accumulative effect on analgesia. Conclusion: EA could produce immediate analgesia action and have an accumulative effect.