1[1]Nelson A R, Singleton B, Rothenberg M L, et al. Matrix metalloproteinases: biolo gic activity and clinical implications. Clin Oncol, 2000,18∶1135.
2[2]Curran S, Murray G I. Matrix metall opro teinases. molecular aspects of their rol es in tumor invasion and metastasis. Eur J Cancer, 2000,36∶1621.
3[3]Gomez D E, Alonso D F, Yosiji H,et al. T issue inhibitors of metalloproteinses: s tructure, regulation and biological func tions. Eur J Cell Biol, 1997,74∶111.
4[4]Hamasaki T, Hattori T, Kimura G, e t al . Tumor progression and expression of ma trix metallopoteinase-2(MMP-2)mRNA by hu man urinary biadder cancer cells. Urol Res, 1998, 26∶371.
5[5]Furukawa A, Tsuji M, Nishtani M, et a l. Role of the matrix metalloproteinase and tissue inhibitors of metalloproteins familoes in noninvasive and invasive tu mors transplanted in mice with severe co mbined immunodeficiency. Urol, 1998,51(5 )∶849.
6[6]Kawamata H, Kameyama S, Kawai K, e t al . Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cel l line by the expression of human gelati nase A. Int J Cancer, 1995,63∶568.
7[7]Kawamata H, Kawai K, Kameyama S, e t al . Over-expressin of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIM P2) suppresses extravasation of pulmonar y metastasis of a rat bladder carcinoma. Int J Cancer, 1995, 63∶680.
8[8]Itoh T, Tanioka M, Yoshida H, et a l. R educed angiogenesis and tumor progressio n in gelatinase A deficienct mice. Cance r Res, 1998, 58∶1048.
9[9]McCawley L J, Matrisian L M. Matrix metal oroteinases: multifunctional contributor s to tumor progression. Mol Med Today, 2 000,6∶149.
10[10]Ivaska J, Heino J. Adhesion recep tors and cell invasion: mechanisms of integr in-guided degradation of extracellular m atrix. Cell Mol Life Sci, 2000,57(1)∶16.
5Kleiner D E,Stetler-Stevenson W G.Matrix metalloproteinases and metastasis[J].Cancer Chemother Pharmacol,1999,43 (Suppl):42-51.
6Jass J R,Sobin L H.Histological typing of intestinal tumors.World Health Organization international histological classification of Tumors[M].2nd ed.New York:Springer-Verlag,1989.
7Muller D,Wolf C,Abecassis J,et al.Increased stromelysin 3gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas[J].Cancer Res,1993,53(1):165-169.
8Bodey B,Bodey B Jr,Siegel S E,et al.Prognostic significance of matrix metalloproteinases expression in colorectal carcinomas[J].In Vivo,2000,14(5):659-666.
