脑出血患者血肿周围水肿形成机制:脑内细胞因子的作用

Mechanisms of Perihematomal Brain Edema Formation in Patients with Cerebral Hemorrhage the Potential Role of Inflammatory Cytokines

目的 :探讨脑出血患者脑内炎性细胞因子与血肿周围水肿的形成是否相关。方法 :32例脑出血患者行血肿清除术后 ,留取脑血肿液 ,放免法测定其中肿瘤坏死因子α(TNFα)和白细胞介素 - 6 (IL - 6 )的含量 ,测量术前检查的头 CT上的血肿周围水肿带大小 ,用 SPSS10 0对两者进行相关分析。结果 :脑出血患者脑血肿液中 IL - 6和 TNFα的含量明显高于正常人溶血血清中的含量 (P<0 .0 1) ;脑血肿液中 TNFα和 IL - 6含量与血肿周围水肿带大小呈正相关 (r TNF=0 .5 39,P<0 .0 1;r IL- 6 =0 .5 6 9,P<0 .0 1)。结论 :脑出血患者急性期脑血肿液中 IL - 6和 TNFα含量升高 ;

Objective:To explore the correlation between perihematomal brain edema and inflammatory cytokines in brain. Methods: Cerebral hematoma fluid of thirty two patients who suffer from cerebral hemorrhage and treated by craniopuncture were collected. The content of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNFα) were determined by method of radioimmunoassay (RIA). The size of perihematomal brain edema on computed tomographic (CT) scan is determined before the operation. The correlation of the two variable is analyzed with statistics package for social science (SPSS 10.0). Results: The levels of IL 6 and TNFα of cerebral hemorrhage patients'cerebral hematoma fluid were apparently higher than those of normal hemolytic blood (P<0.01). Between the size of perihematomal brain edema and the contain of IL 6 and TNFα in cerebral hematoma fluid, positive correlation is significant at the 0.01 level (r TNF =0.539; r IL 6=0.569 . Conclusion: The results showed that there are high level of IL 6 and TNFα in cerebral hematoma fluid of the patients who suffer from cerebral hemorrhage in the acute stage and it's possible inflammatory cytokines in brain is concerned with perihematomal brain edema formation.\;