糖尿病肾病患者凝血与纤溶平衡变化的研究

Abnormal balance of coagulation and fibrinolysis in diabetic nephropathy

目的 探讨糖尿病肾病患者的凝血、纤溶状态。方法 35例 2型糖尿病、糖尿病肾病 (DN)患者和慢性肾小球肾炎 (CGN)患者 2 9例 ,按是否合并肾病综合征 (NS)分为 :DN- NNS组 19例 ,DN- NS组 16例 ,CGN- NNS组 16例 ,CGN- NS组 13例。酶联免疫吸附法系统检测各项凝血和纤溶指标。结果 无论是否合并 NS,DN患者较 CGN组血中TM、PF1 + 2 、TAT、FPA及 PAI-水平明显增加。

Objective To investigate the states of coagulation and fibrinolysis in diabetes nephropathy.Methods Thirty five patients with type 2 diabetes and diabetic nephropathy (DN) and twenty nine patients with chronic glomerulonephritis (CGN) were divided into four groups according to with or without nephritic syndrome (NS). Those included 19 DN patients without NS as DN NNS group, 16 DN patients with NS as DN NS group, 16 CGN patients without NS as CGN NNS group and 13 CGN patients with NS as CGN NS group. The parameters of coagulation fibrinolysis were measured by ELISA.Results Regardless of whether with or without NS, the levels of thrombomodulin, prothrombin fragment 1+2, thrombin antithrombin Ⅲ complex, fibrinopeptid A and plasminogen activator inhibitor 1 were significantly higher in DN patients compared with CGN patients.Conclusion Compared with CGN patients, DN patients have more hypercoagulation state.