复方银参颗粒对大鼠脑缺血损伤的保护作用

Protective Effects of Compound Yinshen Granules on Cerebral Ischemia Injuries in Rats

目的 :研究复方银参颗粒 (FYSG)对大鼠缺血性脑损伤的药理作用。方法 :采用Tamura法建立大鼠大脑中动脉阻断模型 ,观察大鼠脑梗塞面积、卒中行为评级 ,测定脑组织水含量、脑指数。结果 :FYSG (10 0g/kg、5 0g/kg)能明显缩小大脑中动脉阻断大鼠脑梗塞面积 ,改善卒中大鼠神经症状 ,降低脑组织含水量、脑指数。结论 :FYSG对大鼠缺血性脑组织损伤具有保护作用。

OBJECTIVE:To study the pharmacological actions of compound Yinshen granules(CYSG) on cerebral ischemia injuries in rats METHODS:Using an established middle cerebral artery occlusion(MCAO)model devised by Tamura,we observed infarction areas of the brain and behaviour grade of cerebral apoplexy,and calculated brain water content and brain index RESULTS:CYSG(10 0g/kg,5 0g/kg in rats)significantly reduced infarction areas,ameliorated neurological symptoms,decreased brain water content and brain index after MCAO in rats CONCLUSION:CYSG can protect ischemia cerebral injuries in rats