摘要
目的 :评价皮肤角质层和真皮层对药物经皮吸收的差异。方法 :选择氢醌 (HQ)为模型药物 ,采用Franz吸收池法 ,考察药物经完整皮肤和剥离角质层皮肤的体外透皮能力Kp ,并比较吸收促进剂肉豆蔻酸异丙酯(IPM)共存时的促透能力大小。结果 :HQ经剥离角质层皮肤的Kp 是经完整皮肤的3 29倍 ,加入IPM后HQ的Kp 分别提高到原来的4 95倍 (经完整皮肤 )和7 49倍 (经剥离角质层皮肤 )。结论 :本实验为皮肤病态条件 ,如皮肤受伤或溃疡等时的药物经皮吸收规律研究提供了一种新的方法。
OBJECTIVE:To investigate the influence of skin layers(stratum corneum and dermis)on the percutaneous absorption of drug.METHODS:We chose hydroquinone(HQ)as a model drug and carried out in vitro permeation experiment with Franz device.The in vitro transdermal permeation was compared between HQ plus isopropyl myristate(IPM)and HQ alone.RESULTS:The permeability coefficient(Kp)of HQ via split skin was 3.29 times larger than that via whole skin layer.The permeability was enhanced 4.95 times(whole skin layer)and 7.49 times(skin without stratum corneum)respectively when coexisting with IPM via intact or via split skin.CONCLUSION:These data and methods represent a novel approach to evaluate the effects of skin damage and skin disease on drug percutaneous absorption.
出处
《中国药房》
CAS
CSCD
2002年第4期208-209,共2页
China Pharmacy
关键词
氢醌
肉豆蔻酸异丙酯
剥离角质层
经皮吸收
hydroquinone
isopropyl myristate
skin without stratum corneum
percutaneous absorption
