我院1998年～2001年抗抑郁药物的应用分析

Analysis of Antidepressants Used in Our Hospital During the Period 1998～2001

目的 :了解我院抗抑郁药的应用状况及发展趋势。方法 :采用金额排序和频度分析方法对我院1998年～2001年抗抑郁药的应用情况进行统计分析。结果 :抗抑郁药的年用药金额及用药频度 (DDDs)逐年提高 ,2001年各种抗抑郁药年用药金额及DDDs分别是1998年的3 69倍和2 14倍。三环类抗抑郁药所占金额比例虽然不高 ,但其DDDs连续4年列前5位的药有氯米帕明和多塞平。新型抗抑郁药因其副作用相对少而轻 ,治疗地位不断上升 ,所占金额比例较高。结论 :三环类抗抑郁药仍是治疗抑郁症的首选 ;新型抗抑郁药应用前景广阔 ;尚需加速开发治疗抑郁症的中药。

OBJECTIVE:To get clear idea about the current situation and future trend of use of antidepressants METHODS:By using the methods of order of sum of money and DDDs,the antidepressants used in our hospital in years 1998～2001 were analysed RESULTS:The annual sum of money and DDDs of antidepressants were increasing and the sum of money and DDDs of antidepressants used in 2001 were 3 69 times and 2 14 times as much as those in 1998,respectively Although the proportion of sum of money of tricyclic antidepressants(TCAs) was lower than that of new type antidepressants(NTAs),Clomipramine hydrochloride and Doxepin belonging to TCAs were in the first five places in order of DDDs during the past four years Because of the low price and less side effect,the position of NTAs in therapy of depressions was increasing CONCLUSION:TCAs are still the first choice in therapy of depressions The prospects of NTAs will be wide and bright It is important to speed up the development of Chinese materia medica in therapy of depressions