载脂蛋白B基因多态性与中青年人动脉粥样硬化性脑梗死关系的研究

The relationship between polymorphism of apolipoprotein B gene and atherosclerotic cerebral infarction in the youth

目的 探讨ApoB基因多态性与中青年人动脉粥样硬化性脑梗死 (ACI)的相关关系。 方法 用PCR技术检测了健康中青年人 10 0名和中青年ACI病人 36例的ApoB基因多态性及血脂、脂蛋白和载脂蛋白的含量。结果 ApoB基因XbaⅠX+ X-基因型频率ACI为 14 .7% ,高于对照组的 4 .7% (P <0 .0 5 ) ;ACI组TG、TC、Lp(a)含量明显高于对照组 ,HDL -C含量显著低于对照组 (P <0 .0 1) ;ACI病人中X+ X-组的ApoAⅠ明显低于X-X-组 (P <0 .0 2 5 )。结论 ApoBXbaⅠ基因X+

Objective To investigate the relationship between the genetic polymorphism of apolipoprotein(Apo) B and young adults ACI.Methods The polymerase chain reaction(PCR) technique was used to study the polymorphisms of ApoB gene and allele frequencies in 100 age matched Chinese healthy controls and 36 patients with ACI. The levels of the lipid and lipoproteins were also compared between the cases of ACI and the controls.Results The prevalence of the X +X - phenotype was significantly greater in patients than control subjects. The frequency of the X + allele was not significant in patients compared with control subjects. There were significant differences between ACI patients and healthy controls for TG, TC, LP(a) and HDL C. ApoA Ⅰ level in ACI patients with X +X - was significantly lower ( P < 0.025 ) than that in patients with X -X -. Conclusion X + of ApoB Xba Ⅰ may have a relationship with ACI in the youth.