几种不同预测大鼠肝脏体积(重量)方法的比较

Comparison of different methods for predicting liver volume (weight) of rats

目的 研究大鼠肝脏CT扫描结果与实际肝脏重量和体积的关系 ,建立术前、术后间接预测肝脏体积的方法。方法 30只SD大鼠 ,用肝脏CT扫描的方法测定大鼠肝脏的体积 ,同时测定大鼠的体重 ,处死大鼠后测定鼠肝的重量、体积及各叶的重量 ,用直线回归的方法探讨肝脏重量与肝体积、体重、体表面积及CT测定肝体积的关系。结果 30只大鼠肝脏重量 (1 1 .1 4± 1 .55)g与肝脏体积 (1 1 .2 0± 1 .51 )cm3数值基本相等 ,肝脏各叶重量占全肝重量中的比例相对恒定 ,肝脏重量与大鼠体重、体表面积及CT测定的肝脏体积分别具有线性依存关系 ,其差异有非常显著性(P<0 .0 1 ) ,CT预测各叶肝重与肝脏各叶重量之间差异无显著性 (P >0 .0 5)。结论 根据大鼠的体重、体表面积及CT扫描肝体积与大鼠肝重相关性 ,可以预测大鼠各叶肝重 ,用于小移植物的实验研究 。

Objective To establish a method for predicting the partial liver volume of SD rats according to liver computed tomography (CT) scan,which would help to the study of small graft in partial liver transplantation.Method Spiral CT (plain and enhanced) was performed on 30 rats to measure the liver volume and the body weight of rats and liver weight were measured simultaneously.The relationship between liver weight and liver volume,body weight,body surface area or CT calculated volume was explored by linear regression.Results Liver weight (11.14±1.55)?g in 30 rats and that of liver volume (11.20±1.51)?cm 3 were almost the same and the ratio of every lobe in the total liver was constant.The relationship between the weight of the liver and body weight,body surface and the calculated CT volume was linear (P<0.01).Moreover,the CT technique was found to be more accurate than others.Conclusion The liver volume can be predicted through rat body weight,body surface area,and CT scan.CT scan can evaluate the liver volume of every lobe,which can be used in the research of the small graft.