非小细胞肺癌Ki-67的表达及其意义

Expression and Clinical Evaluation of Ki-67 in Non-Small Lung Cancer

目的 探讨非小细胞肺癌 Ki- 67的表达及其意义。方法 采用免疫组化 En Vision二步法对 46例非小细胞肺癌石蜡标本进行 Ki- 67检测 ,并结合临床病理资料作结果分析。结果 Ki- 67阳性表达率为 65.2 % (30 /46) ,与性别、年龄、肿瘤直径大小、组织学类型及分化程度无明显相关性 ,但与淋巴结转移情况密切相关 ,随着淋巴结转移程度的进展 ,其阳性率也逐渐升高 ,N2 、N3 组与 N0 组比较差异显著 (P<0 .0 5)。结论 在非小细胞肺癌中检测 Ki- 67的表达对判断和预测淋巴结转移或评估预后有一定指导意义。

Objective To investigate the expression of Ki 67 in non small cell lung cancer(NSCLC)and its significance.Methods 46 samples of NSCLC were detected by EnVision immunochemical method.Results The incidence of Ki 67 expression was 65 2%(30/46).There was no statistical correlation between the expression of Ki 67 and sex,age,T stage,histologic type and cytoplasmic differentiation(P>0 05),but it correlated with the metastasis of lymphonodus,the expression rate was positively correlated with the degree of metastasis.The positive rate of Ki 67 in group N 2?N 3 was significant higher than that in group N 0(P<0 05).Conclusion The detection of Ki 67 may help to predict the metastasis of lymphonodus and estimate prognosis in NSCLC.