抑郁与缺血性心脏病相关性的研究进展

Study of the Association between Depression and Ischemic Heart Disease

缺血性心脏病常伴发抑郁。越来越多的证据表明潜在的心理生理学机制导致了抑郁与缺血性心脏病相关非常紧密。临床研究表明,抑郁是心脑血管疾病发病的重要危险因素,可能与血小板的活化有关。临床医护人员应对那些缺血性心脏病并发抑郁的患者保持高度的重视,尤其是那些从急性心脏事件中恢复的患者。此外,抑郁的发生不利于缺血性心脏病患者的康复。目前,研究尚未确定社会心理治疗及药物治疗对抑郁治疗的效果。

Depression is a mmon morbidity associated with ischemic heart disease (IHD). There is growing evidence suggest a psychophysiologic mechanism underlying the vulnerability of depressed patients to IHD. Clinical studies have demonstrated that depression is associated with a much higher risk of both cardiovascular morbidity and mortality, which could be caused by platelet activation. Physicians should maintain a heightened level of clinical suspicion for depression and depressive disorders in patients with IHD, particularly those individuals who are recovering from an acute ischemic event. Furthermore, depression may complicate the recovery of IHD, whether psy-chosocial intervention or pharmacologic therapy for the treatment of depression is beneficial is not certain.