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胰腺癌组织DPC4/Smad4　mRNA表达的临床意义 被引量：3

The expression of DPC4/Smad4 mRNA in pancreatic carcinoma tissue
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摘要 目的 观察DPC4/Smad4 mRNA在胰腺癌组织中的表达及其临床意义。方法 应用原位杂交技术对23例胰腺癌组织中的DPC4/Smad4 mRNA表达进行研究。结果 胰腺癌组织中DPC4/Smad4 mRNA表达率为52.2％（12/23）,低于癌周组织表达率9/10。统计学分析显示,DPC4/Smad4mRNA表达与胰腺癌病理分级呈显著相关（P<0.05）,与胰腺癌临床分期及有无局部淋巴结转移间无显著相关（P>0.05）。结论 DPC4/Smad4 mRNA基因表达有可能作为胰腺癌诊断与鉴别诊断的生物学指标之一。 Objective The aim of the study was to observe the expression of DPC4/Smad4 mRNA in pancreatic carcinoma and to analyse the relationship between expression of DPC4/Smad4 mRNA and clinical manifestations. Methods The expression of DPC4/Smad4 mRNA in pancreatic carcinoma and pericancerous tissue were detected by in situ hybridization method. Results The positive rates of DPC4 mRNA in pancreatic carcinoma and pericancerous tissue were 52. 2% (12/23) and 9/10 respectively. The expression of DPC4 mRNA was related to the degree of cell differentiation of pancreatic carcinoma, but no relation was found between the DPC4 mRNA expression and the clinical stage or the status of lymph node metastasis. Conclusions The results suggest that DPC4/ Smad4 is an important tumor suppressive gene that is frequently deletable in pancreatic carcinoma. Inactivation of DPC4 may play a role in the carcinogenesis of pancreatic carcinoma.
作者 周国雄 李兆申 许国铭 屠振兴 刘枫
机构地区 第二军医大学附属长海医院消化科
出处 《胰腺病学》 2002年第1期25-27,共3页 Chinese JOurnal of Pancreatology
关键词 基因表达 临床意义 肿瘤生物学 鉴别诊断 胰腺癌 DPC4/SMAD4 MRNA Pancreatic carcinoma DPC4/Smad4 In situ hybridization
分类号 R735.9 [医药卫生—肿瘤]
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参考文献8

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同被引文献26

  • 1柳洋,文继舫,李景和,肖德胜,胡忠良,罗庚求.DPC4基因转染对结肠癌细胞生长的抑制作用及其作用机制[J].中华病理学杂志,2004,33(3):247-250. 被引量：9
  • 2耿志坚,陈晓峰,乔庆,童淑兰,方立德,徐亮,李强,陈维香,丁珺.肺癌中p53及nm23与多药耐药基因表达的相关分析及预后意义[J].中国肿瘤临床与康复,2005,12(1):10-12. 被引量：5
  • 3童向东,刘宏旭,赵惠儒,许世广,李玉,韩立波,张林.Smad4蛋白与蛋白激酶在非小细胞肺癌信号传导通路中的作用[J].中华肿瘤杂志,2006,28(10):741-745. 被引量：18
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胰腺病学
2002年 第1期

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